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The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics


Ten healthy subjects were given 20 mg of warfarin orally before, and after a daily intake of 400 g of brussels sprouts for 2 weeks. The brussels sprouts diet stimulated warfarin disposal as evidenced by a 29% increase in mean elimination rate constant, accompanied by a 27% increase in metabolic clearance rate and a 16% decrease in plasma AUC. It is concluded that a high intake of brussels sprouts, a cruciferous vegetable, accelerates warfarin disposal, and thereby might contribute to less anticoagulation.

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  1. Duxbury BMcD (1982) Therapeutic control of anticoagulant treatment. Br Med J 284: 702–704

    Google Scholar 

  2. Hamberg O, Ovesen L, Hess K, Olesen ES (1986) A vegetable rich diet reduces the response to oral anticoagulants. In: Wahlquist ML, Trusswell AS (eds) Recent advances in clinical nutrition, vol 2. Libbey, London, pp 319–320

    Google Scholar 

  3. Loub WD, Wattenberg LW, Davis DW (1975) Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants. JNCI 54: 985–998

    Google Scholar 

  4. Pantuck EJ, Hsiao KC, Loub WD, Wattenberg LW, Kuntzman R et al. (1976) Stimulatory effect of vegetables on intestinal drug metabolism in the rat. J Pharmacol Exp Ther 198: 278–283

    Google Scholar 

  5. Welle-Watne A, Jahren G (1980) Analysis of warfarin in plasma by high performance liquid chromatography. Medd Norsk Farm Selsk 42: 45–52

    Google Scholar 

  6. Owren PA (1959) Thrombotest. A new method for controlling anticoagulant therapy. Lancet 2: 254–258

    Google Scholar 

  7. Anderson KE, Conney AH, Kappas A (1979) Nutrition and oxidative drug metabolism in man: relative influence of dietary lipids, carbohydrate, and protein. Clin Pharmacol Ther 26: 493–501

    Google Scholar 

  8. Kappas A, Anderson KE, Conney AH, Alvares AP (1976) Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin Pharmacol Ther 20: 643–653

    Google Scholar 

  9. Krishnaswami K, Kalamegham R, Naidu NA (1984) Dietary influence on the kinetics of antipyrine and aminopyrine in human subjects. Br J Clin Pharmacol 17: 139–146

    Google Scholar 

  10. Proia AD, McNamara DJ, Edwards DG, Anderson KE (1981) Effects of dietary pectin and cellulose on hepatic and intestinal mixed-function oxidations and hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in the rat. Biochem Pharmacol 30: 2553–2558

    Google Scholar 

  11. Pantuck EJ, Pantuck CB, Garland WA, Min BH, Wattenberg LW et al. (1979) Stimulatory effect of brussels sprouts and cabbage on human drug metabolism. Clin Pharmacol Ther 25: 88–95

    Google Scholar 

  12. Parrish D (1980) Determination of vitamin K in food. CRC Crit Rev Food Sci Nutr 13: 337–352

    Google Scholar 

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Ovesen, L., Lyduch, S. & Idorn, M.L. The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics. Eur J Clin Pharmacol 34, 521–523 (1988).

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Key words

  • warfarin
  • vegetables
  • oral anticoagulants
  • drug-nutrient interaction