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The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics

Summary

Ten healthy subjects were given 20 mg of warfarin orally before, and after a daily intake of 400 g of brussels sprouts for 2 weeks. The brussels sprouts diet stimulated warfarin disposal as evidenced by a 29% increase in mean elimination rate constant, accompanied by a 27% increase in metabolic clearance rate and a 16% decrease in plasma AUC. It is concluded that a high intake of brussels sprouts, a cruciferous vegetable, accelerates warfarin disposal, and thereby might contribute to less anticoagulation.

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Ovesen, L., Lyduch, S. & Idorn, M.L. The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics. Eur J Clin Pharmacol 34, 521–523 (1988). https://doi.org/10.1007/BF01046714

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Key words

  • warfarin
  • vegetables
  • oral anticoagulants
  • drug-nutrient interaction