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European Journal of Clinical Pharmacology

, Volume 34, Issue 5, pp 521–523 | Cite as

The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics

  • L. Ovesen
  • S. Lyduch
  • M. L. Idorn
Short Communications

Summary

Ten healthy subjects were given 20 mg of warfarin orally before, and after a daily intake of 400 g of brussels sprouts for 2 weeks. The brussels sprouts diet stimulated warfarin disposal as evidenced by a 29% increase in mean elimination rate constant, accompanied by a 27% increase in metabolic clearance rate and a 16% decrease in plasma AUC. It is concluded that a high intake of brussels sprouts, a cruciferous vegetable, accelerates warfarin disposal, and thereby might contribute to less anticoagulation.

Key words

warfarin vegetables oral anticoagulants drug-nutrient interaction 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • L. Ovesen
    • 1
  • S. Lyduch
    • 1
  • M. L. Idorn
    • 1
  1. 1.Nutrition Laboratory, KommunehospitaletCopenhagenDenmark

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