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Production of extracellular 5-aminolevulinic acid byClostridium thermoaceticum grown in minimal medium

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Summary

A growth associated formation of extracellular 5-aminolevulinic acid (ALA) was found in the homoacetogenesis of glucose byClostridium thermoaceticum grown in minimal defined medium. The growth and ALA production was enhanced by L-cysteine HCl both in complex medium (UM) and minimal defined medium (MDM). The amount of ALA produced extracellularly in MDM wasca. 15 mg/L after 90-h anaerobic cultivation (cell-mass: 1.5 g/l; glucose consumed: 20 g/l).

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Authors and Affiliations

  1. Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Saijo-cho, 724, Higashi Hiroshima-shi, Japan

    Koesnandar, Shoji Ago, Naomichi Nishio & Shiro Nagai

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  1. Koesnandar
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  2. Shoji Ago
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  3. Naomichi Nishio
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  4. Shiro Nagai
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Koesnandar, Ago, S., Nishio, N. et al. Production of extracellular 5-aminolevulinic acid byClostridium thermoaceticum grown in minimal medium. Biotechnol Lett 11, 567–572 (1989). https://doi.org/10.1007/BF01040037

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