Summary
A patient with prolymphocytic leukemia is described. The peripheral blood and bone-marrow cells contained nuclear pockets, bridges, and appendices, as well as cytoplasmic inclusions that were not membrane bound or connected with the endoplasmic reticulum. X-ray microanalysis of the cells showed them to contain large amounts of phosphorus, sulfur, chlorine, and calcium, as well as a smaller amount of sodium and magnesium in comparison with control lymphocytes. When compared with lymphocytes of a patient with chronic lymphocytic leukemia (CLL), the patient's cells showed higher amounts of magnesium, sulfur, and chlorine, while the sodium content was decreased. The usefulness of electron microscopy and X-ray microanalysis in the diagnosis of this type of leukemia is discussed.
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Abbreviations
- CLL:
-
chronic lymphocytic leukemia
- SEM:
-
scanning electron microscopy
- TEM:
-
transmission electron microscopy
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Djaldetti, M., Eisbruch, A., Perek, J. et al. Cytoplasmic inclusions and X-ray microprobe analysis in a case of prolymphocytic leukemia. J Cancer Res Clin Oncol 107, 229–232 (1984). https://doi.org/10.1007/BF01032613
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DOI: https://doi.org/10.1007/BF01032613