Summary
There new diaziridine platinum(II) complexes(4a)-(4c), and a new azetidine platinum(II) complex (3b) were synthesized and tested against the lymphocytic leukemia P388 in mice.
Moderate to good activity was found for all compounds as evidenced by a T/C value of 162 at a dose of 32 mg/kg for (3b), 190 at a dose of 32 mg/kg for (4a), 139 at a dose of 4 mg/kg for (4b), and 142 at a dose of 20 mg/kg for (4c).
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Part VI. Sosnovsky G, Paul BD, (1983) Z. Naturforsch [B] 38:1146–1155
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Sosnovsky, G., Lukszo, J. In the search for new anticancer drugs. VII. J Cancer Res Clin Oncol 107, 217–220 (1984). https://doi.org/10.1007/BF01032610
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DOI: https://doi.org/10.1007/BF01032610