Chemistry of Heterocyclic Compounds

, Volume 5, Issue 1, pp 112–114 | Cite as

Azaindole derivatives

XXVI. The formation of 5,7-diazaindoline derivatives by the reaction of 4-chloro-5-(β-chloroethyl)pyrimidines with secondary amines
  • L. N. Yakhontov
  • M. S. Sokolova
  • N. I. Koretskaya
  • K. A. Chkhikvadze
  • O. Yu. Magidson
  • M. V. Rubtsov
Article
  • 24 Downloads

Abstract

It has been shown that the closure of the pyrroline ring with simultaneous N-dealkylation observed previously for the reactions of 2- and 4-chloro-3-(β-chloroethyl)pyrimidines with secondary amines has a general nature and is suitable for the synthesis of 5,7-diazaindoline derivatives from 4-chloro-5-(β-chloroethyl)pyrimidines. Features of the structure of 5,7-diazaindoline systems connected with the electron-accepting properties of the nitrogen atom of the pyrimidine nucleus are discussed.

Keywords

Nitrogen Organic Chemistry Nitrogen Atom Pyrimidine General Nature 

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References

  1. 1.
    L. N. Yakhontov, M. A. Portnov, M. Ya. Uritskaya, D. M. Krasnokutskaya, M. S. Sokolova, and M. V. Rubtsov, ZhOrKh,3, 580, 1967.Google Scholar
  2. 2.
    K. A. Chkhikvadze, N. I. Koretskaya, N. S. Rodnyanskaya, and O. Yu. Magidson, KhGS [Chemistry of Heterocyclic Compounds],5, 138, 1969.Google Scholar
  3. 3.
    L. N. Yakhontov and M. V. Rubtsov, ZhOKh,31, 3281, 1961.Google Scholar
  4. 4.
    L. N. Yakhontov and M. V. Rubtsov, ZhOKh, collection: Biologically Active Compounds [in Russian], p. 90, 1965.Google Scholar
  5. 5.
    L. N. Yakhontov and M. V. Rubtsov, ZhOKh,34, 493, 1964.Google Scholar

Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • L. N. Yakhontov
    • 1
  • M. S. Sokolova
    • 1
  • N. I. Koretskaya
    • 1
  • K. A. Chkhikvadze
    • 1
  • O. Yu. Magidson
    • 1
  • M. V. Rubtsov
    • 1
  1. 1.Ordzhonikidze All-Union Chemical and Pharmaceutical Scientific-Research InstituteMoscow

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