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A practical chemoenzymic route to (S)-(−)-propranolol

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Summary

A practical and economical (compared to methods employing chiral epichlorohydrin) synthesis of the β-blocker (S)-propranolol [1-isopropylamino-3(1-naphthyloxy)-2-propanol] starting from 2-O-acetyl-1,3-dichloropropanol, 1,3-dichloropropanol or epichlorohydrin has been achieved with the enzymic resolution of the epoxy intermediate (1) as the key step.

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Authors and Affiliations

  1. Indian Institute of Chemical Technology, 500 007, Hyderabad, India

    T. N. B. Kaimal, R. B. N. Prasad & T. Chandrasekhara Rao

Authors
  1. T. N. B. Kaimal
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  2. R. B. N. Prasad
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  3. T. Chandrasekhara Rao
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IICT Communication No.: 2945

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Kaimal, T.N.B., Prasad, R.B.N. & Rao, T.C. A practical chemoenzymic route to (S)-(−)-propranolol. Biotechnol Lett 14, 21–26 (1992). https://doi.org/10.1007/BF01030908

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