Zusammenfassung
Bei zwei Patienten mit akuter myeloischer Leukämie wurde durch die G- und C-Bandenanalyse der Knochenmarkzellen neben der Translokation t(8;21) eine zusätzliche strukturelle Anomalie nachgewiesen, die durch die Deletion der Banden q13 bis q23 eines Chromosoms Nr. 9 gekennzeichnet ist. Diese Konstellation stellt einen Subtyp des typischen Karyotyps der AML dar.
Summary
Two patients with acute myeloid leukemia are described in whom G- and C-banding analysis of bone marrow cells revealed, besides the translocation t(8;21), an additional structural anomaly characterized by the deletion of bands q13 to q23 of one chromosome no. 9. Findings in the literature support the proposal that this constellation represents a hitherto unreported subtype of the prototypic karyotype in AML.
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References
Hart, J.S., Trujilulo, J. M., Freireich, E. J., George, S.L.: Cytogenetic studies and their clinical correlates in adults with acute leukemia. Ann. Intern. Med.75, 353–360 (1971)
Hossfeld, D.K.: Identification of chromosomal anomalies in the blastic phase of CML by Giemsa- and Quinacrine banding techniques. Hum. Genet.23, 111–118 (1974)
Hossfeld, D.K.: Additional chromosomal indication for the unicellular origin of chronic myelocytic leukemia. Z. Krebsforsch.83, 269–273 (1975)
Hossfeld, D.K.: Faltermaier, M.T., Schmidt, C. G.: Therapieergebnisse der akuten nichtlymphoblastischen Leukämie bei Erwachsenen. Dtsch. Med. Wochenschr.45, 1595–1599 (1979)
Kamada, N., Okada, K., Ito, T., Nakatsui, T., Uchino, H.: Chromosomes 21–22 and neutrophil alkaline phosphatase in leukemia. LancetI, 364 (1968)
Kamada, N., Okada, K., Oguma, N., Tanaka, R., Mikami, M., Uchino, H.: C-G translocation in acute myelocytic leukemia with low neutrophil alkaline phosphatase activity. Cancer37, 2380–2387 (1976)
Kaneko, Y., Sakurai, M., Hattori, M.: A case of acute myelogenous leukemia with an 8–21 translocation, missing Y, and additional karyotypic abnormalities. Am. J. Hematol.4, 273–280 (1978)
Mitelman, E., Levan, G.: The chromosomes of primary7, 12 dimethylbenz(α)anthraceneinduced rat sarcomas. Hereditas71, 325–331 (1972)
Philip, P., Jensen, M.K., Killmann, S.Aa., Drivholm, A., Hansen, N.E.: Chromosomal banding patterns in 88 cases of acute nonlymphocytic leukemia. Leukemia Res.2, 201–212 (1978)
Rowley, J.D.: Identification of a translocation with Quinacrine fluorescence in a patient with acute leukemia. Ann. Genet.16, 109–112 (1973)
Rowley, J.D., Golomb, H.M., Vardiman, J., Fukuhara, S., Dougherty, C., Potter, D.: Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia. Int. J. Cancer20, 869–872 (1977)
Sakurai, M., Oshimura, M., Kakati, S., Sandberg, A.A.: 8-21 translocation and missing sex chromosomes in acute leukemia. LancetII, 227–228 (1974)
Sakurai, M., Sandberg, A.A.: Chromosomes and causation of human cancer and leukemia. XL Correlation of karyotypes with clinical features of acute myeloblastic leukemia. Cancer37, 285–299 (1976)
Teerenhovi, L., Borgström, G.H., Mitelman, F., Brandt, L., Vuopio, P., Timonen, T., Almqvist, A., De La Chapelle, A.: Uneven geographical distribution of 15; 17-translocation in acute promyelocytic leukemia. LancetII, 797 (1978)
Trujillo, J.M., Ahearn, M. J., Youness, E. L., McCredie, K.B.: Hematologic and cytologic characterization of 8/21 translocation acute granulocytic leukemia. Blood53, 695–706 (1979)
Trujillo, J.M., Cork, A., Hart, J.S., George, S.L., Freireich, E. J.: Clinical implications of aneuploid cytogenetic profiles in adult acute leukemia. Cancer33, 824–834 (1974)
Van den Berghe, H., David, G., Broechaert-Van Orshoven, A., Louwagie, A., Verwilghen, R., Casteels-Van Daele, M., Eggermont, E., Eeckels, R.: A new chromosome anomaly in acute lymphoblastic leukemia (ALL). Hum. Genet.46, 173–180 (1979)
Zech, L., Haglund, U., Nilson, K., Klein, G.: Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. Int. J. Cancer17, 47–56 (1976)
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Supported by the Deutsche Forschungsgemeinschaft (SFB 102)
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Hossfeld, D.K., Higi, M., Köhler, S. et al. A subtype of the prototypic karyotype in acute myeloid leukemia t (8; 21) (q22; q22), del 9 (q13; q23). Blut 40, 27–32 (1980). https://doi.org/10.1007/BF01028361
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DOI: https://doi.org/10.1007/BF01028361