Journal of Materials Science

, Volume 14, Issue 1, pp 197–204 | Cite as

Developments in the biomedical evaluation of silicone rubber

  • R. van Noort
  • M. M. Black
  • B. Harris


Passive prosthetic devices, for example artificial heart valves, can be manufactured from elastomeric materials such as silicone rubber. This paper describes how optimum properties for a medical grade heat-vulcanizing silicone rubber can be best achieved. The paper will also describe how the properties of these materials are affected by the different cleaning and sterilization procedures which may be used. Thein vivo response of this silicone rubber to subcutaneous implantation in guinea pigs has been investigated for periods of up to ten months. Scanning electron microscopy of the surfaces of these elastomers has been performed. As a result, it has been possible to perform detailed examinations of the topological features of the surfaces prior to and after implantation.


Polymer Silicone Electron Microscopy Scan Electron Microscopy Rubber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    E. Greener andE. Lautenschlager, “Biomedical Engineering” (F. A. Davis Co. Philadelphia, 1971) p. 287.Google Scholar
  2. 2.
    A. S. Hoffman,Trans. Amer. Soc. Artif. Int. Organs 18 (1972) 10.Google Scholar
  3. 3.
    P. Fredecki,J. Biomed. Mater. Res. 8 (1974) 487.Google Scholar
  4. 4.
    A. Starr, W. Pierie, D. Raible, M. Edwards, G. Siposes andW. D. Hancock,Circulation Suppl. I 3 (1966) 115.Google Scholar
  5. 5.
    M. S. Morgan,Abst. Papers Amer. Chem. Soc. 57 (1973) 73.Google Scholar
  6. 6.
    R. E. Hawker,Med. J. Australia 1 (1971) 205.Google Scholar
  7. 7.
    J. C. Hylen,Annal. Thor. Surg. 13 (1972) 4.Google Scholar
  8. 8.
    M. M. McHenry,J. Thor. Cardiovasc. Surg. 59 (1970) 413.Google Scholar
  9. 9.
    A. B. Swanson,Surg. Clinic N. Amer. 8 (1968) 1113.Google Scholar
  10. 10.
    W. D. Meesters andA. B. Swanson,J. Biomed. Mater. Res. 6 (1972) 193.Google Scholar
  11. 11.
    N. Ring, private communication, Chailey Heritage, Sussex (1975).Google Scholar
  12. 12.
    H. P. Chin, E. C. Harrison, D. H. Blakenhorn andJ. Moacanin,Circulation Suppl. I 43 (1971) 51.Google Scholar
  13. 13.
    R. I. Leiniger, V. Mirkovitch, A. Peters andW. A. Hawks,Trans. Amer. Soc. Artific. Int. Organs 10 (1964) 320.Google Scholar
  14. 14.
    J. W. Swanson, J. E. Le Beau,J. Biomed. Mater. Res. 8 (1974) 357.Google Scholar
  15. 15.
    R. VanNoort, B. Harris andM. M. Black, Pri. Conference Proceedings “Plastics in Medicine and Surgery”. Glasgow (1975).Google Scholar
  16. 16.
    E. Nyilas, E. L. Kupski, P. Burnett andR. M. Haag,J. Biomed. Mater. Res. 4 (1970) 369.Google Scholar
  17. 17.
    B. Bloch andG. W. Hastings, “Plastics Materials in Surgery” (C. C. Thomas, Springfield, Illinois, 1972) Ch. VI.Google Scholar

Copyright information

© Chapman and Hall Ltd. 1979

Authors and Affiliations

  • R. van Noort
    • 1
  • M. M. Black
    • 1
  • B. Harris
    • 2
  1. 1.Department of Medical PhysicsUniversity of SheffieldUK
  2. 2.Department of Materials ScienceUniversity of BathUK

Personalised recommendations