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Optimisation of L-lysine production byCorynebacterium sp in fed-batch cultures

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Summary

The influence of initial concentration of glucose from 60 to 233 g/l on the production of L-lysine byCorynebacterium sp was studied first in batch culture. The maximum conversion rate into L-lysine was obtained at 165 g/l and the best specific production rate for L-lysine was observed at 65 g/l of glucose. In fed-batch fermentations, better conversion and the specific production rates were obtained. Maintaining of a high glucose concentration in the fed-batch technique allowed a 54% increase of the L-lysine production compared to the batch culture.

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Authors and Affiliations

  1. Division des Procédés Biotechnologiques, Université de Technologie de Compiègne, BP 233, 60206, COMPIEONE, (FRANCE)

    Hadj Sassi A., Queric M. P., Deschamps A. M. & Lebeault J. M.

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  1. Hadj Sassi A.
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  2. Queric M. P.
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  3. Deschamps A. M.
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  4. Lebeault J. M.
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Hadj, S.A., Queric, M.P., Deschamps, A.M. et al. Optimisation of L-lysine production byCorynebacterium sp in fed-batch cultures. Biotechnol Lett 10, 583–586 (1988). https://doi.org/10.1007/BF01027134

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  • DOI: https://doi.org/10.1007/BF01027134

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