Biotechnology Letters

, Volume 10, Issue 7, pp 479–484 | Cite as

Effects of reduced oxygen on growth and antibiotic production inStreptomyces clavuligerus

  • P. K. Yegneswaran
  • M. R. Gray
  • D. W. S. Westlake


The effects of reduced oxygen on growth and antibiotic production were studied in batch cultures ofStreptomyces clavuligerus in defined media. Antibiotic levels were unaffected by reduced oxygen for the first 50 hours of fermentation. After growth ceased, antibiotic concentrations dropped by a factor of about three under reduced oxygen, while the antibiotic concentration was stable when air was used. This suggests that enzymes for hydrolyzing antibiotics may be regulated by the aeration conditions.


Oxygen Enzyme Fermentation Organic Chemistry Aeration 
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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • P. K. Yegneswaran
    • 1
  • M. R. Gray
    • 1
  • D. W. S. Westlake
    • 2
  1. 1.Department of Chemical EngineeringUniversity of AlbertaEdmontonCanada
  2. 2.Department of MicrobiologyUniversity of AlbertaEdmontonCanada

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