Biotechnology Letters

, Volume 10, Issue 5, pp 331–336 | Cite as

Production of actinomycin D with immobilizedStreptomyces parvullus under nitrogen and carbon starvation conditions

  • Mina Dalili
  • Pao C. Chau


The productivity of actinomycin D withStreptomyces parvullus could be enhanced with calcium alginate immobilized cells and a synthetic starvation medium in a continuous air-lift bioreactor with moderately low dilution rate. In addition, the cell mass must be cycled periodically between the growth and starvation media to maintain long-term antibiotic production.


Nitrogen Calcium Alginate Bioorganic Chemistry Cell Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aharonowitz, Y (1980).Ann. Rev. Microbiol. 34, 209–233.Google Scholar
  2. Arcuri, E.J., Nichols, J.R., Brix, T.S., Santamarina, V.G., Buckland, B.C. and Drew, S.W. (1983).Biotechnol. Bioeng. 25, 2399–2411.Google Scholar
  3. Bailey, J.E. and Ollis, D.F. (1986). Biochemical Engineering Fundamentals, 2nd ed., McGraw-Hill, p.468.Google Scholar
  4. Deo, Y.M. and Gaucher, G.M. (1984).Biotechnol. Bioeng. 26, 285–295.Google Scholar
  5. Foster, J.W. and Katz, E. (1981).J. Bact. 148, 670–677.Google Scholar
  6. Gallo, M. and Katz, E. (1972).J. Bacteriol. 109, 659–667.Google Scholar
  7. Gbewonyo, K. and D.I.C. Wang (1983).Biotechnol. Bioeng. 25, 967–983.Google Scholar
  8. Kim, J.H., Oh, D.K., Park, S.K. and Park, Y.H. (1986).Biotechnol. Bioeng. 28, 1838–1844.Google Scholar
  9. Koopman, B., Lau, A.O., Storm, P.E. and Jenkins, D. (1980).Biotechnol. Bioeng. 22, 2433–2435.Google Scholar
  10. Rehg, T., Dorger, C. and Chau, P.C. (1986).Biotechnol. Lett. 8, 111–114.Google Scholar
  11. Robertson, C.R. and Kim, I.H. (1985).Biotechnol. Bioeng. 27, 1012–1020.Google Scholar
  12. Williams, K.W. and Katz, E. (1977).Antimicrob. Agents Chemother. 11, 281–290.Google Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Mina Dalili
    • 1
  • Pao C. Chau
    • 2
  1. 1.North Carolina State UniversityUSA
  2. 2.Department of AMES (Chemical Engineering)University of CaliforniaSan Diego

Personalised recommendations