Abstract
Amino acid sequences of pilin from a strain of Bacteroides nodosus from serogroup B (234) and serogroup C (217) were determined. The amino-terminal N-methylphenlalanine residue of both proteins was followed by a hydrophobic sequence of 30 residues closely related to the N-terminal sequence of other pili having an amino-terminal residue of N-methylphenylalanine. These data lend support to the hypothesis that in pilins of this type, the amino-terminal sequence functions as a transport signal necessary for pilin to reach its external environment, as well as promoting intersubunit interactions for muintenance of the structural integrity of the pilus. Two hydrophilic hypervariable regions can be discerned across the pilin sequences, indicating possible locations of antigenic domains.
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McKern, N.M., Stewart, D.J. & Strike, P.M. Amino acid sequences of pilins from serologically distinct strains ofBacteroides nodosus. J Protein Chem 7, 157–164 (1988). https://doi.org/10.1007/BF01025245
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DOI: https://doi.org/10.1007/BF01025245