Biotechnology Letters

, Volume 14, Issue 7, pp 543–546 | Cite as

Penicilin acylase mediated synthesis of formyl cefamandole

  • Claudio Fuganti
  • Cristina M. Rosell
  • Romina Rigoni
  • Stefano Servi
  • Auro Tagliani
  • Marco Terreni
Article

Summary

Penicillin acylase-catalyzed synthesis from D,L-methyl mandelate (1c) and the cefalosporin nucleus (2) at pH 6 gives rise preferentially to the L-diastereoisomer (3a) of cefamandole, whereas D,L-O-formyl methyl mandelate (1f) affords exclusively O-formyl cefamandole (cefamandole nafate) (4), in 30–35% yields.

Keywords

Methyl Organic Chemistry Penicillin Bioorganic Chemistry Mandelate 

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References

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Claudio Fuganti
    • 1
  • Cristina M. Rosell
    • 2
  • Romina Rigoni
    • 1
  • Stefano Servi
    • 1
  • Auro Tagliani
    • 1
  • Marco Terreni
    • 1
  1. 1.Dipartimento di Chimica del PolitecnicoCentro CNR di Studio delle Sostanze Organiche NaturaliMilanoItaly
  2. 2.Instituto de Catalisis y PetrolquimicaC.S.I.C.MadridSpain

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