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ImmobilizedAspergillus terreus in itaconic acid production from glucose

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Summary

The production of itaconic acid by immobilizedAspergillus terreus TKK 200-5-1 was studied both in shake flask cultures, and in continuous column bioreactors. The effect of glucose and ammonium nitrate concentrations, and of pH were examined using a statistical experimental plan. The highest itaconic acid product concentration could be reached at the highest investigated glucose concentration of 150 g/l and the highest initial pH of 3.75, in the absence of ammonium nitrate. In a continuous packed bed column system operated fro 4.5 months itaconic acid was obtained at a productivity of 328 mg/d per gram of polyurethane foam carrier.

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Author notes

  1. Nikolay Vassilev

    Present address: Institute of Microbiology, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

Authors and Affiliations

  1. Laboratory of Biotechnology and Food Engineering, Helsinki University of Technology, SF-02150, Espoo, Finland

    Nikolay Vassilev, Helena Kautola & Yu-Yen Linko

Authors
  1. Nikolay Vassilev
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  2. Helena Kautola
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  3. Yu-Yen Linko
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Vassilev, N., Kautola, H. & Linko, YY. ImmobilizedAspergillus terreus in itaconic acid production from glucose. Biotechnol Lett 14, 201–206 (1992). https://doi.org/10.1007/BF01023359

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