Biotechnology Letters

, Volume 16, Issue 1, pp 69–74

Ammonium regulation inSaccharopolyspora erythraea. Part II: Regulatory effects under different nutritional conditions

  • Jean Potvin
  • Paul Péringer

DOI: 10.1007/BF01022626

Cite this article as:
Potvin, J. & Péringer, P. Biotechnol Lett (1994) 16: 69. doi:10.1007/BF01022626


Non-limiting nutritional conditions revealed a growth-associated erythromycin production with ammonium sulfate while the relation was growth-dissociated for ammonium nitrate. Feeding experiments suggested that the residual nitrate level might be the key regulatory element. A nitrate-induced glutamine synthetase pathway was postulated according to the nature and initial concentration of the ammonium salt.

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Jean Potvin
    • 1
  • Paul Péringer
    • 2
  1. 1.Zeneca Bio ProductsN.A.T.C.MississaugaCanada
  2. 2.Laboratoire de Génie biologiqueEcole Polytechnique Fédérale de LausanneLausanneSuisse

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