Biotechnology Letters

, Volume 16, Issue 1, pp 7–10 | Cite as

Effect of support matrix on ratio of product to by-product formation in L-phenylacetyl carbinol synthesis

  • Penka Nikolova
  • Owen P. Ward


Production of L-phenylacetyl carbinol (PAC) and benzyl alcohol by biotransformation from pyruvate and benzaldehyde substrates was investigated using yeast cells in different polymeric matrices. Highest concentration of PAC was produced by cells immobilised in the hydrophilic matrix, ENT-4000. Highest concentration of the by-product, benzyl alcohol, was produced in the hydrophobic matrix, ENTP-2000. Ratio of PAC to benzyl alcohol ranged from 1∶0.08 for cells entrapped in a poly(propyleneglycol)-containing polymer, PU-3, to 1∶1.8 for cells entrapped in ENTP-2000 polymer.


Polymer Alcohol Organic Chemistry Pyruvate Yeast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Penka Nikolova
    • 1
  • Owen P. Ward
    • 1
  1. 1.Microbial Biotechnology Laboratory, Department of BiologyUniversity of WaterlooWaterlooCanada

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