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Fed-batch fermentation of glucose to acetate by an improved strain ofClostridium thermoaceticum

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Abstract

The fed-batch approach to the production of acetate from glucose by an improved strain ofClostridium thermoaceticum resulted in better performance than the batch fermentation, especially in media containing an excess (3X) of nutrients and trace salts. At pH 6.6, 46 g/l acetic acid was produced in 192 hours with 93% substrate utilization. In contrast, batch fermentation under similar conditions resulted in a maximum of 35 g/l acetic acid with less than 82% substrate utilization.

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Authors and Affiliations

  1. Agricultural Bioprocess Laboratory, University of Illinois, 1302 W. Pennsylvania Avenue, 61801, Urbana, IL, USA

    Sarad Parekh & Munir Cheryan

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  1. Sarad Parekh
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  2. Munir Cheryan
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Parekh, S., Cheryan, M. Fed-batch fermentation of glucose to acetate by an improved strain ofClostridium thermoaceticum . Biotechnol Lett 12, 861–864 (1990). https://doi.org/10.1007/BF01022611

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