Abstract
A current model of amino acid chemoreception has generated the idea that pH affects the efficiency of stimulus-receptor binding by altering the charge distribution on stimulus molecules. The model suggests that amino acids are maximally stimulatory near their isoelectric points. We point out that, within a broad range of pH values, changes in stimulant amino acids cannot account for altered chemoresponsiveness. We suggest instead that pH-induced changes in chemoreception are a result of changes in charge distribution on the protein receptor.
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Bauer, U., Dudel, J., andHatt, H. 1981. Characteristics of single chemoreceptive units sensitive to amino acids and related substances in the crayfish leg.J. Comp. Physiol. 144:67–74.
Caprio, J. 1982. High sensitivity and specificity of olfactory and gustatory receptors of catfish to amino acids, pp. 109–134,in T.J. Hara (ed.). Chemoreception in Fishes. Elsevier, New York.
Dixon, M., andWebb, E.C. 1979. Enzymes. Academic Press, New York.
Edsall, J.T. 1943a. Dipolar ions and acid-base equilibria, pp. 75–115,in E.J. Cohn and J.T. Edsall (eds.). Proteins, Amino Acids and Peptides. Reinhold, New York.
Edsall, J.T. 1943b. Proteins as acids and bases, pp. 444–505,in E.J. Cohn and J.T. Edsall (eds.). Proteins, Amino Acids and Peptides. Reinhold, New York.
Hara, T.J. 1976a. Structure-activity relationships of amino acids in fish olfaction.Comp. Biochem. Physiol. 54A:31–36.
Hara, T.J. 1976b. Effects of pH on the olfactory responses to amino acids in rainbow trout,Salmo gairdneri.Comp. Kochem. Physiol. 54A:37–39.
Hara, T.J. 1982. Structure-activity relationships of amino acids as olfactory stimuli, pp. 135–137,in T.J. Hara (ed.). Chemoreception in Fishes. Elsevier, New York.
Hatt, H. 1984. Structural requirements of amino acids and related compounds for stimulation of receptors in crayfish walking leg.J. Comp. Physiol. A. 155:219–231.
Jones, K.A., Hara, T.J., andScherer, E. 1985. Behavioral modifications in arctic char (Salvelinus alpinus) chronically exposed to sublethal pH.Physiol. Zool. 58:400–412.
Laidler, K.J. 1958. The Chemical Kinetics of Enzyme Action, Oxford University Press, Oxford.
Lehninger, A.L. 1975. Biochemistry. Worth, New York.
Lemly, A.D., andSmith, J.F. 1985. Effects of acute exposure to acidified water on the behavioral response of fathead minnows,Pimephales promelas, to chemical feeding stimuli.Aquat. Toxicol. 6:25–36.
Novoselov, V.I., Krapivinskaya, L.D., andFesenko, E.E. 1980. Molecular mechanisms of odor sensing. V. Some biochemical characteristics of the alanineous receptor from the olfactory epithelium of the skateDasyatis pastinaca.Chem. Senses 5:195–203.
Royce-Malmgren, C.H., andWatson, W.H., III. 1987. Acidified water reversibly alters the behavioral response of Atlantic salmon (Salmo salar) to olfactory stimuli.J. Chem. Ecol. 13:533–546.
Shallenberger, R.S., Acree, T.E., andLee, C.Y. 1969. Sweet taste of D and L sugars and amino acids and the steric nature of their chemoreceptor site.Nature 221:555–556.
Tierney, A.J., andAtema, J. 1986. Effects of acidification on the behavioral response of crayfishes (Orconectesvirilis andProcambarus acutus) to chemical stimuli.Aquat. Toxicol. 9:1–11.
Valentincic, T. 1984. Behavioral study of chemoreception in the sea starMarthasterias glacialis: Structure-activity relationships of lactic acid, amino acids, and acetylcholine.J. Comp. Physiol. A. 157:537–545.
Yoshii, K., Kamo, N., Kurihara, K., andKobatake, Y. 1979. Gustatory responses of eel palatine receptors to amino acids and carboxylic acids.J. Gen. Physiol. 74:301–317.
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Tierney, A.J., Atema, T. Amino acid chemoreception: Effects of ph on receptors and stimuli. J Chem Ecol 14, 135–141 (1988). https://doi.org/10.1007/BF01022537
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DOI: https://doi.org/10.1007/BF01022537