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Optimization of recombinantEscherichia coli fed-batch fermentation for bovine somatotropin

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Summary

Optimum specific growth rate for the production of recombinant bovine somatotropin (bST) was investigated in fed-batchE. coli fermentation with a controlled specific growth rate. Maximum specific bST concentration based on cell mass decreases linearly with the controlled specific growth rate. Productivity of bST is expressed by a quadratic equation as a function of the specific growth rate and has a maximum value at μ=0.23 hr−1.

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Authors and Affiliations

  1. Lucky Biotech Research Institute, P.O. Box 10, Daejeon, Korea

    Sung Kwan Yoon, Seon Hun Kwon, Myoung Gyu Park & Whan Koo Kang

  2. Department of Genetic Engineering, Sung Kyun Kwan University, 300 Chunchun-dong, 440-746, Suwon, Korea

    Tai Hyun Park

Authors
  1. Sung Kwan Yoon
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  2. Seon Hun Kwon
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  3. Myoung Gyu Park
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  4. Whan Koo Kang
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  5. Tai Hyun Park
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Yoon, S.K., Kwon, S.H., Park, M.G. et al. Optimization of recombinantEscherichia coli fed-batch fermentation for bovine somatotropin. Biotechnol Lett 16, 1119–1124 (1994). https://doi.org/10.1007/BF01020836

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  • DOI: https://doi.org/10.1007/BF01020836

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