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Effect of propionic acid on poly (β-hydroxybutyric-co-β-hydroxyvaleric) acid production byAlcaligenes eutrophus

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Summary

The effect of propionic acid on poly(β-hydroxybutyric-co-β-hydroxyvaleric)acid P(HB-co-HV) copolymer production byAlcaligenes eutrophus ATCC 17699 supplied with fructose and propionic acid under nitrogen limited conditions was studied. The growth ofA. eutrophus was almost completely inhibited when the concentraion, of propionic acid exceeds 1.5 g/L. Specific production rate of HV unit was highest when propionic acid concentration was 0.5 g/L. In batch culture, pH change occurs in proportion to the consumption of propionic acid. Optimal concentration of propionic acid was maintained during the production phase by using a pH-stat feeding method and a total polymer content higher than 70% and the relative HV content upto 50% could be achieved.

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Authors and Affiliations

  1. Department of Chemical Technology College of Engineering, Seoul National University, 151-742, Seoul, Korea

    J. H. Kim, B. G. Kim & C. Y. Choi

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  1. J. H. Kim
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  2. B. G. Kim
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  3. C. Y. Choi
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Kim, J.H., Kim, B.G. & Choi, C.Y. Effect of propionic acid on poly (β-hydroxybutyric-co-β-hydroxyvaleric) acid production byAlcaligenes eutrophus . Biotechnol Lett 14, 903–906 (1992). https://doi.org/10.1007/BF01020626

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  • DOI: https://doi.org/10.1007/BF01020626

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