Influence of adrenergic β-receptor activity on blood flow and free fatty acid release in canine subcutaneous adipose tissue during hemorrhagic shock
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Irreversible hemorrhagic shock was produced in dogs by means of a standardized bleeding procedure. Blood flow and net release of free fatty acids were measured in subcutaneous adipose tissue. Infusion of isoprenaline (0.5 μg/kg/ min i.v.) prevented the severe vasoconstriction during bleeding and promoted the net release of free fatty acids. Futhermore, isoprenaline infusion made it possible to restore a normal blood flow after reinfusion of the shed blood in contrast to the case in control animals. Propranolol (1 mg/kg i.v.) decreased the arterial free fatty acid concentration in the resting animal and also increased the mortality rate.
It is concluded thatβ-receptor stimulation by isoprenaline prevents the vascular damage in canine subcutaneous adipose tissue during development of hemorrhagic shock.
Key-wordsHemorrhage Isoprenaline Propranolol Shock Adipose Tissue Blood Flow Fatty Acids
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