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, Volume 39, Issue 5, pp 351–357 | Cite as

Erythrocyte rheology in acute cerebral thrombosis effects of ABO blood groups

  • D. A. Ionescu
  • M. Ghitescu
  • I. Marcu
  • A. Xenakis
Original Works

Summary

Within a few hours after a cerebral thrombosis in 220 patients, the flow-properties of the red blood cells (RBC) were analyzed by a filtration test that expresses quantitatively the deformability and aggregability of the RBC by the filtration indexes pT. Abnormal deformability of the RBC washed clean of plasma was found in 27.5% of the patients. Aggregability disorders, caused by the plasma trapped between the unwashed RBC, were found in 78.6 % of the patients: computation of correlation coefficients between pT indexes and fibrinogen, which was found abnormally high in 88.2% of cases, demonstrated significantly that in the patients with A and B blood groups these aggregability disorders were due to fibrinogen and that they were caused by other components of plasma in patients with O and AB blood groups. All these disorders can account for blood hyperviscosity.

Key words

Cerebral thrombosis Erythrocyte deformability and aggregability Blood groups 

Flie\eigenschaften der Erythrozyten bei Patienten mit akutem zerebralen GefÄ\verschlu\

Zusammenfassung

Innerhalb weniger Stunden nach Bildung eines Thrombus in einer Hirnarterie wurden bei 220 Patienten die DeformabilitÄt and AggregabilitÄt der Erythrozyten untersucht. Die Filtration von gewaschenen Erythrozyten zeigte bei 27,5% der Patienten VerÄnderungen der DeformabilitÄt. Die Filtration ungewaschener Erythrozyten ergab bei 78,6% der Patienten eine Zunahme der AggregabilitÄt der Erythrozyten. Die Berechnung der Korrelationskoeffizienten zwischen Filtrations-index und Fibrinogenkonzentration, die bei 88,2% der Patienten erhöht war, weist darauf hin, da\ Störungen der AggregabilitÄt nur bei Patienten mit den Blutgruppen A und B abhÄngig von Fibrinogen sind, wÄhrend es sich bei den Blutgruppen 0 und AB um andere Plasmafaktoren handeln mu\.

Schlüsselwörter

Hirnthrombose DeformabilitÄt und AggregabilitÄt der Erythrozyten Blutgruppen 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • D. A. Ionescu
    • 1
  • M. Ghitescu
    • 2
  • I. Marcu
    • 2
  • A. Xenakis
    • 2
  1. 1.Institute of Neurology and PsychiatryBucharestRumania
  2. 2.Centre of HaematologyBucharestRumania

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