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, Volume 39, Issue 5, pp 309–315 | Cite as

Enzymes of the purine interconversion system in chronic lymphatic leukemia: Decreased purine nucleoside phosphorylase and adenosine deaminase activity

  • H. Ludwig
  • R. Kuzmits
  • H. Pietschmann
  • M. M. Müller
Original Works

Summary

Activities of adenosine deaminase (ADA), adenosine kinase (AK), adenine phosphoribosyltransferase (APRT), hypoxanthine guanine phosphoribosyltransferase (HGPRT), and purine nucleoside phosphorylase (PNP), all enzymes of the purine interconversion system, were determined in lymphocytes of 25 patients with chronic lymphatic leukemia (CLL) and in 23 controls. A statistically significant decrease of PNP activities and a reduction of ADA activities at borderline levels were found in the patients, whereas for the other enzymes assayed no deviation from normal values was observed.

Key words

Chronic lymphatic leukemia Purine interconversion system enzyme activities Purine nucleoside phosphorylase Adenosine deaminase 

Enzyme des Purin-Interconversionssystems bei chronisch-lymphatischer LeukÄmie: Verminderte PNP und ADA AktivitÄt

Zusammenfassung

Bei 25 Patienten mit chronisch-lymphatischer LeukÄmie (CLL) und 23 Kontrollpersonen wurden die AktivitÄten der Purin-Interconversionsenzyme Adenosin Deaminase (ADA), Adenosin Kinase (AK), AdeninPhosphoribosyltransferase (APRT), Hypoxanthin-Guanin-Phosphoribosyl-transferase (HGPRT) und Purin-Nucleosid-Phosphorylase (PNP) bestimmt. Dabei konnte bei den Patienten mit CLL eine statistisch signifikant verminderte PNP-AktivitÄt sowie eine grenzwertig reduzierte ADA-AktivitÄt festgestellt werden, wÄhrend die AktivitÄten der anderen untersuchten Purin-Interconversionsenzyme im Normalbereich lagen.

Schlüsselwörter

Chronisch-lymphatische LeukÄmie Enzyme des Purin-Interconversionssystems Purin-Nucleosid-Phosphorylase Adenosin-Deaminase 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • H. Ludwig
    • 1
    • 2
    • 3
  • R. Kuzmits
    • 1
    • 2
    • 3
  • H. Pietschmann
    • 1
    • 2
    • 3
  • M. M. Müller
    • 1
    • 2
    • 3
  1. 1.II. Medizinische UniversitÄtsklinikWienAustria
  2. 2.Institut für Medizinische Chemie der UniversitÄt WienWienAustria
  3. 3.Ludwig-Boltzmann-Institut für GerontologieWienAustria

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