Skip to main content
SpringerLink
Log in

The contribution made by cytochemistry to the study of the metabolism of the normal and rheumatoid synovial lining cell (synoviocyte)

  • Review
  • Published:
The Histochemical Journal Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Arch, J. R. S. &Newsholme, E. A. (1978) The control of the metabolism and the hormonal role of adenosine.Essays Biochem. 14, 82–123.

    Google Scholar 

  • Baker, J. R. (1946) The histochemical recognition of lipine.Q. Jl microsc. Sci. 87, 441–70.

    Google Scholar 

  • Balaz, E. A., Watson, D., Duff, I. F. &Roseman, S. (1967) Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritic human fluids.Arth. Rheum. 10, 357–76.

    Google Scholar 

  • Ball, J. (1969) Post-mortem findings and articular pathology in rheumatoid arthritis. InRheumatic Diseases (edited byDuthie, J. J. R. andAlexander, W. R. M.), p. 123. Edinburgh: Edinburgh University Press.

    Google Scholar 

  • Ball, J., Chapman, J. A. &Muirden, K. D. (1964) The uptake of iron in rabbit synovial tissue following intra-articular injection of iron dextran. A light and electron microscope study.J. Cell. Biol. 22, 351–64.

    Google Scholar 

  • Barland, P. &Hamerman, D. (1962) Studies on oxidative and hydrolytic enzymes in synovial membrane of normal and arthritic patients.Bull. N. Y. Acad. Med. 38, 507–8.

    Google Scholar 

  • Barland, P., Novikoff, A. B. &Hamerman, D. (1962) Electron microscopy of the human synovial membrane.J. Cell Biol. 14, 207–20.

    Google Scholar 

  • Barland, P., Novikoff, A. B. &Hamerman, D. (1964) Fine structure and cytochemistry of the rheumatoid synovial membrane, with special reference to lysosomes.Am. J. Path. 44, 853–9.

    Google Scholar 

  • Bitensky, L., Butcher, R. G. &Chayen, J. (1973) Quantitative cytochemistry in the study of lysosomal function. InLysosomes in Biology and Pathology (edited byDingle, J. T.), Vol. 3, p. 465. Amsterdam: North Holland.

    Google Scholar 

  • Bitensky, L., Butcher, R. G., Johnstone, J. J. &Chayen, J. (1974) Effect of glucocorticoids on lysosomes in synovial lining cells in human rheumatoid arthritis.Ann. rheum. Dis. 33, 57–61.

    Google Scholar 

  • Bitensky, L., Cashman, B., Chayen, J., Henderson, B., Higgs, G. A., Salmon, J. A. & Vane, J. R. (1980) Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and non-rheumatoid synovial tissue.Proc. Br. Pharmacol. Soc., 57–8.

  • Bitensky, L., Cashman, B., Johnstone, J. J. &Chayen, J. (1977) Effect of glucocorticoids on the hexosemonophosphate pathway in human rheumatoid synovial lining cellsin vitro andin vivo.Ann. rheum. Dis. 36, 448–52.

    Google Scholar 

  • Blau, S., Janis, R., Hamerman, D. &Sandson, J. (1965) Cellular origin of hyaluronate-protein in the human synovial membrane.Science 150, 353–5.

    Google Scholar 

  • Butcher, R. G., Bitensky, L., Cashman, B. &Chayen, J. (1973) Differences in the redox balance in human rheumatoid and non-rheumatoid synovial lining cells.Beitr. Path. 148, 265–74.

    Google Scholar 

  • Bywaters, E. G. L. (1937) The metabolism of joint tissues.J. Path. Bact. 44, 247–68.

    Google Scholar 

  • Castor, C. W. (1960) The microscopic structure of normal human synovial tissue.Arth. Rheum. 3, 140–51.

    Google Scholar 

  • Castor, C. W., Prince, R. K. &Dorstewitz, E. L. (1962) Characteristics of human ‘fibroblasts’ cultivatedin vitro from different anatomical sites.Lab. Invest. 11, 703–13.

    Google Scholar 

  • Chamberlain, M. A. &Keenan, J. (1976) The effect of low doses of prednisolone compared with placebo on function and on the hypothalamic pituitary adrenal axis in patients with rheumatoid arthritis.Rheum. Rehabil. 15, 17–23.

    Google Scholar 

  • Chaplin, D. M. (1971) The pattern of bone and cartilage damage in the rheumatoid knee.J. Bone Jt Surg. 53B, 711–7.

    Google Scholar 

  • Chayen, J. (1968) The histochemistry of phospholipids and its significance in the interpretation of the structure of cells. InCell Structure and its Interpretation (edited byMcGee-Russell, S. M. andRoss, K. F. A.), p. 149. London: Arnold.

    Google Scholar 

  • Chayen, J. (1977) Problems of redox measurements in cell physiology.Proc. Analyt. Div. Chem. Soc. 14, 342–5.

    Google Scholar 

  • Chayen, J. (1978) Microdensitometry. InBiochemical Measurements of Liver Injury (edited bySlater, T. F.), p. 257. London, New York: Academic Press.

    Google Scholar 

  • Chayen, J., Bitensky, L., Butcher, R. G. &Cashman, B. (1971) Evidence for altered lysosomal membranes in synovial lining cells from human rheumatoid joints.Beitr. Path. 142, 137–49.

    Google Scholar 

  • Chayen, J., Bitensky, L., Butcher, R. G. &Cashman, B. (1973) The effect of experimentally induced redox changes in human rheumatoid and non-rheumatoid synovial tissuein vitro.Beitr. Path. 149, 127–44.

    Google Scholar 

  • Chayen, J., Bitensky, L. &Ubhi, G. S. (1972) The experimental modification of lysosomal dysfunction by anti-inflammatory drugs actingin vitro.Beitr. Path. 147, 6–20.

    Google Scholar 

  • Coulton, L. A., Henderson, B., Bitensky, L. &Chayen, J. (1980) DNA synthesis in human rheumatoid and nonrheumatoid synovial lining.Ann. rheum. Dis. 39, 241–7.

    Google Scholar 

  • Coulton, L. A., Henderson, B. &Chayen, J. (1981) The assessment of DNA-synthetic activity.Histochemistry 72, 91–9.

    Google Scholar 

  • Dayer, J.-M., Krane, S. M., Russell, R. G. G. &Robinson, D. R. (1976) Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.Proc. natn. Acad. Sci., U.S.A. 73, 945–9.

    Google Scholar 

  • Dayer, J.-M., Robinson, D. R. &Krane, S. M. (1977) Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear cells.J. exp. Med. 145, 1399–404.

    Google Scholar 

  • Dingle, J. T. (1962) Lysosomal enzymes and the degradation of cartilage matrix.Proc. R. Soc. Med. 55, 109–11.

    Google Scholar 

  • Dingle, J. T. M. &Page Thomas, D. P. (1956)In vitro studies on human synovial membrane. A metabolic comparison of normal and rheumatoid tissue.Br. J. exp. Path. 37, 318–23.

    Google Scholar 

  • Dumonde, D. C. &Glynn, L. E. (1962) The production of arthritis in rabbits by an immunological reaction to fibrin.Br. J. exp. Path. 43, 373–83.

    Google Scholar 

  • Farr, M., Kendall, M. J., Shuttleworth, R., Meynell, M. J. &Hawkins, C. F. (1973) Source and significance of 5′ nucleotidase in synovial fluid.Ann. rheum. Dis. 32, 326–30.

    Google Scholar 

  • Fell, H. B. (1978) Synoviocytes.J. clin. Path. 31, Suppl.12, 14–24.

    Google Scholar 

  • Flower, R. J. (1977) Prostaglandins and related compounds. InInflammation: Mechanisms and their Impact on Therapy (edited byBonta, I. L., Thompson, J. andBrune, K.), p. 99. Stuttgart: Birkhäuser Verlag.

    Google Scholar 

  • Ghadially, F. N. (1978) Fine structure of joints. InThe Joints and Synovial Fluid, Vol. 1 (edited bySokoloff, L.), p. 105. New York, London: Academic Press.

    Google Scholar 

  • Goldfischer, S., Smith, C. &Hamerman, A. (1968) Altered acid hydrolase activities in rheumatoid synovial cells in culture.Am. J. Path. 52, 569–75.

    Google Scholar 

  • Gumaa, K. A., McLean, P. &Greenbaum, A. L. (1971) Compartmentation in relation to metabolic control in liver. InEssays in Biochemistry (edited byCampbell, P. N. andDickens, F.), Vol. 7, p. 39. New York, London: Academic Press.

    Google Scholar 

  • Hamerman, D. &Blum, M. (1959) Histologic studies on human synovial membrane. 2. Localization of some oxidative enzymes in synovial membrane cells.Arth. Rheum. 2, 553–8.

    Google Scholar 

  • Hamerman, D. &Ruskin, J. (1959) Histologic studies on human synovial membrane. 1. Metachromatic staining and the effects of streptococcal hyaluronidase.Arth. Rheum. 2, 546–52.

    Google Scholar 

  • Hamerman, D. &Schuster, H. (1958) Hyaluronate in normal human synovial fluid.J. clin. Invest. 37, 57–64.

    Google Scholar 

  • Henderson, B. (1976) Quantitative cytochemical measurement of glyceraldehyde 3-phosphate dehydrogenase activity.Histochemistry 48, 191–204.

    Google Scholar 

  • Henderson, B. (1977)Quantitative cytochemical studies of rheumatoid arthritis. Ph.D thesis, Brunel University.

  • Henderson, B. (1979) Quantitative dehydrogenase cytochemistry in the study of cellular metabolism with special reference to rheumatoid arthritis. InQuantitative Cytochemistry and its Applications (edited byPattison, J. R., Bitensky, L. andChayen, J.), p. 83. New York, London: Academic Press.

    Google Scholar 

  • Henderson, B. (1981a) The biochemistry of the human synovial lining with special reference to alterations in metabolism in rheumatoid arthritis.Path. Res. Pract. 172, 1–24.

    Google Scholar 

  • Henderson, B. (1981b) Alterations in the activity of lysosomal hydrolases in the synovial lining cell population of the knee joint of the rabbit during the development of chronic arthritis.Path. Res. Pract. 172, 363–71.

    Google Scholar 

  • Henderson, B., Bitensky, L. &Chayen, J. (1978a) Altered phospholipids in human rheumatoid synoviocytes.Ann. rheum. Dis. 37, 24–9.

    Google Scholar 

  • Henderson, B., Bitensky, L. &Chayen, J. (1978c) Mitochondrial oxidative activity in human rheumatoid synovial lining cells.Ann. rheum. Dis. 37, 548–51.

    Google Scholar 

  • Henderson, B., Bitensky, L. &Chayen, J. (1979a) Glycolytic activity in human synovial lining cells in rheumatoid arthritis.Ann. rheum. Dis. 38, 63–7.

    Google Scholar 

  • Henderson, B., Bitensky, L., Johnstone, J. J., Catterall, A. &Chayen, J. (1979b) Metabolic alterations in human synovial lining cells in pigmented villonodular synovitis.Ann. rheum. Dis. 38, 463–6.

    Google Scholar 

  • Henderson, B. &Glynn, L. E. (1981) Metabolic alterations in the synoviocytes in chronically inflamed knee joints in immune arthritis in the rabbit: Comparison with rheumatoid arthritis.Br. J. exp. Path. 62, 27–33.

    Google Scholar 

  • Henderson, B., Glynn, L. E., Bitensky, L. &Chayen, J. (1981) Evidence for cell division in synoviocytes in acutely inflamed rabbit joints.Ann. rheum. Dis. 40, 177–81.

    Google Scholar 

  • Henderson, B., Glynn, L. E. &Chayen, J. (1982a) Experimental allergic arthritis in the rabbit: Alterations in the cellularity and the rate of cellular proliferation in the synovial linings of the challenged joints of rabbits immunized with antigen in Freund's incomplete adjuvant.Br. J. exp. Path. 63, 5–12.

    Google Scholar 

  • Henderson, B., Glynn, L. E. & Chayen, J. (1982b) Cell division in the synovial lining in experimental allergic arthritis: Proliferation of cells during the development of chronic arthritis.Ann. rheum. Dis. (in press).

  • Henderson, B., Johnstone, J. J. &Chayen, J. (1980) 5′ Nucleotidase activity in the human synovial lining in rheumatoid arthritis.Ann. rheum. Dis. 39, 248–52.

    Google Scholar 

  • Henderson, B., Loveridge, N. &Robertson, W. R. (1978b) A quantitative study of the effects of different grades of polyvinyl alcohol on the activities of certain enzymes in unfixed tissue sections.Histochem. J. 10, 453–63.

    Google Scholar 

  • Husby, G., Bankhurst, A. D. &Williams, R. C. (1977) Immunohistochemical localization of prostaglandin E in rheumatoid synovial tissues.Arth. Rheum. 20, 785–91.

    Google Scholar 

  • Janis, R., Sandson, J., Smith, C. &Hamerman, D. (1967) Synovial cell synthesis of a substance immunologically like cartilage protein-polysaccharide.Science 158, 1464–7.

    Google Scholar 

  • Mohr, W., Beneke, G. &Mohing, W. (1975) Proliferation of synovial lining cells and fibroblasts.Ann. rheum. Dis. 34, 219–24.

    Google Scholar 

  • Muirden, K. D. (1972) Lysosomal enzymes in synovial membrane in rheumatoid arthritis: relationship to joint damage.Ann. rheum. Dis. 31, 265–71.

    Google Scholar 

  • Nykänen, P., Helve, T., Kankaanpää, U. &Larsen, A. (1978) Characterization of the DNA-synthesizing cells in rheumatoid synovial tissue.Scand. J. Rheum. 7, 118–22.

    Google Scholar 

  • Page Thomas, D. P. &Dingle, J. T. M. (1955)In vitro studies of rheumatoid synovium. Preliminary metabolic comparison between synovial membrane and villi.Br. J. exp. Path. 36, 195–8.

    Google Scholar 

  • Page Thomas, D. P. &Dingle, J. T. (1958) Studies on the human synovial membranein vitro. The metabolism of normal and rheumatoid synovia and the effect of hydrocortisone.Biochem. J. 68, 231–8.

    Google Scholar 

  • Pandolfi, M., Ahlberg, Å., Traldi, A. &Nilsson, I. M. (1972) Fibrinolytic activity of human synovial membranes in health and haemophilia.Scand. J. Haemat. 9, 572–6.

    Google Scholar 

  • Pugh, D. &Walker, P. G. (1961) The localization ofN-acetyl-β-glucosaminadase in tissues.J. Histochem. Cytochem. 9, 242–50.

    Google Scholar 

  • Roberts, J. E., McLees, B. D. &Kerby, G. P. (1967) Pathways of glucose metabolism in rheumatoid and non-rheumatoid synovial membrane.J. lab. clin. Med. 70, 503–11.

    Google Scholar 

  • Roy, S. &Ghadially, F. N. (1967) Synthesis of hyaluronic acid by synovial cells.J. Path. Bact. 93, 555–7.

    Google Scholar 

  • Storti, E., Magrini, U., Castello, A., Pandolfi, M. &Ascari, E. (1973) The histochemistry of fibrinolysis in haemophilic synovial membranes.Acta haematol. 49, 142–53.

    Google Scholar 

  • Todd, A. S. (1959) The histological localization of fibrinolysin activator.J. Path. Bact. 78, 281–3.

    Google Scholar 

  • Vainio, U. (1966) A histochemical study on leucinaminopeptidase activity in the synovial membrane of patients with rheumatoid arthritis.Ann. rheum. Dis. 25, 253–8.

    Google Scholar 

  • Vainio, U. (1970) Leucinaminopeptidase in rheumatoid arthritis.Ann. rheum. Dis. 29, 434–8.

    Google Scholar 

  • Van De Putte, L. B. A., Kluft, C., Noordhoek Hegt, V., Wijngaards, G., Haverkate, F. &Cats, A. (1977a) Activators and inhibitors of fibrinolysis in rheumatoid joint inflammation. InPerspectives in Inflammation (edited byWilloughby, D. A., Giroud, J. P. andVelo, G. P.), p. 499. Boston: MTP Press.

    Google Scholar 

  • Van De Putte, L. B. A., Noordhoek Hegt, A. &Overbeek, T. E. (1977b) Activators and inhibitors of fibrinolysis in rheumatoid and non-rheumatoid synovial membranes.Arth. Rheum. 20, 671–8.

    Google Scholar 

  • Vaubel, E. (1933) The form and function of synovial cells in tissue cultures. II. The production of mucin.J. exp. Med. 58, 85–95.

    Google Scholar 

  • Waxman, B. A. &Sledge, C. B. (1973) Correlations of histochemical, histologic and biochemical evaluations of human synovium with clinical activity.Arth. Rheum. 16, 376–82.

    Google Scholar 

  • Wegelius, O., Klockars, M. &Vainio, K. (1968) Acid phosphatase activity in rheumatoid synovia.Acta med. scand. 183, 549–51.

    Google Scholar 

  • Weissmann, G. (1964) Lysosomes, autoimmune phenomena and diseases of connective tissue.Lancet 2, 1373.

    Google Scholar 

  • Werb, Z., Mainardi, C. L., Vater, C. A. &Harris, E. D. (1977) Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator.N. Engl. J. Med. 296, 1017–23.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Basic Medical Sciences Group, Chelsea College, University of London, Manresa Road, SW3 6LX, London, UK

    Brian Henderson

Authors
  1. Brian Henderson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Henderson, B. The contribution made by cytochemistry to the study of the metabolism of the normal and rheumatoid synovial lining cell (synoviocyte). Histochem J 14, 527–544 (1982). https://doi.org/10.1007/BF01011886

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01011886

Keywords

Search

Navigation