Journal of Statistical Physics

, Volume 30, Issue 3, pp 755–783 | Cite as

Phase transition in a four-dimensional random walk with application to medical statistics

  • O. E. Percus
  • J. K. Percus
Articles

Abstract

A random walk in a piecewise homogeneous medium can exhibit a variety of asymptotic behaviors. In particular, it may lodge strictly in one region or divide in probability among several. This will depend upon the parameters describing (a) the walk, (b) the interregion boundary, and (c) the initial location of the walk. We analyze from this point of view a special four-dimensional walk on an integer lattice with two homogeneous regions separated by a hyperplane of codimension 1. The walk represents a continuing sequence of clinical trials of two drugs of unknown success probabilities and the two regions represent the Bayes-derived criterion as to which drug to try next. The demarcation in the parameter space of success probabilities and initial coordinates between one- and two-region asymptotics is mapped out analytically in several special cases and supporting numerical evidence given in the general case.

Key words

Phase transition random walk integer lattice clinical trials piecewise homogeneous 

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • O. E. Percus
    • 1
  • J. K. Percus
    • 1
  1. 1.Courant Institute of Mathematical SciencesNew York UniversityNew York

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