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Influence of penicillin instability on interpretation of feedback regulation experiments

  • Eirik Nestaas
  • Arnold L. Demain
Industrial Microbiology

Summary

The stability of penicillin G during production is reviewed and compared to reports on end-product regulation of penicillin biosynthesis. From this analysis, it appears that penicillin control of its own synthesis when added exogenously at the beginning of the process has not been proven, since the apparent decrease of net accumulation can be explained by gradual hydrolysis of the added penicillin. It is also concluded that the maximum amount of penicillin accumulated normally is not controlled by penicillin, but rather by its stability and the ability of the cells to maintain a high synthetic rate over extended time periods.

Keywords

Hydrolysis Penicillin Maximum Amount Feedback Regulation Regulation Experiment 
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References

  1. Benedict RG, Schmidt WH, Coghill RD (1946) The stability of penicillin in aqueous solution. J Bacteriol 51:291–292Google Scholar
  2. Demain AL (1957) Stability of benzylpenicillin during biosynthesis. Antibiot Chemother 7:361–362Google Scholar
  3. Gordee EZ, Day LE (1972) Effect of exogenous penicillin on penicillin biosynthesis. Antimicrob Ag Chemother 1:315–321Google Scholar
  4. Nestaas E (1980) Quantitative characterization of mycelial biomass and morphology using the filtration probe in the penicillin fermentation. Ph.D. Dissertation, Massachusetts Institute of Technology, CambridgeGoogle Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Eirik Nestaas
    • 1
  • Arnold L. Demain
    • 1
  1. 1.Department of Nutrition and Food ScienceMassachusetts Institute of TechnologyCambridgeUSA

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