Summary
Serum of patients suffering from a chronic myeloproliferative disorder (polycythaemia, vera, osteomyelofibrosis, chronic myeloid leukaemia) and serum of lethally irradiated rats injected before application of a single dosis of erythropoietin did not enhance the effect of erythropoietin — measured with the iron incorporation rate of polycythemic mice.
The rationale for these experiments is to try to find a “myeloproliferative factor”, which augments the number of stem cells as described in sera of patients with polycythaemia vera, osteomyelofibrosis, and lethally irradiated mice.
Zusammenfassung
Die Injektion von Serum von Patienten mit chronischem myeloproliferativem Syndrom (Polycythaemia vera, Osteomyelofibrose, chronischer Myelose) und Serum von letal bestrahlten Ratten vor Injektion einer einzelnen Dosis Erythropoetin, verstärkt die Wirkung dieser Erythropoetindosis — gemessen mittels der Eiseneinbaurate polyglobuler Mäuse — nicht.
Der Grund für diese Experimente ist die Suche nach einem „myeloproliferativen Faktor“, der die Zahl der Stammzellen vermehrt. Dieser Faktor wurde im Serum von Patienten mit Polycythaemia vera und Osteomyelofibrose sowie im Serum von letal bestrahlten Mäusen beschrieben.
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Essers, U., Nowak, H. Zur Frage der Existenz eines myeloproliferativen Faktors bei Patienten mit myeloproliferativem Syndrom. Blut 39, 107–115 (1979). https://doi.org/10.1007/BF01008086
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DOI: https://doi.org/10.1007/BF01008086