Zusammenfassung
Die erste Isolierung und Charakterisierung eines Lymphokins, des menschlichen MIF (MSF), und die Gewinnung eines spezifischen MIF (MSF)-Antikörpers eröffnen die Möglichkeit, neue Parameter für die Bestimmung zellulärer Immunmechanismen bei verschiedenen klinischen Situationen zu gewinnen. Die genaue quantitative Bestimmung mit empfindlichen immunochemischen Techniken könnte einen Einblick in die Pathogenese verschiedener klinischer Erkrankungen ermöglichen. Zusätzlich könnte der quantitativen Bestimmung von MIF in Körperflüssigkeiten eine prognostische Bedeutung zukommen.
Summary
The first isolation and characterization of a lymphokine, the human MIF (MSF), and the availability of a specific MIF (MSF)-antibody provide an opportunity to establish a new parameter for detection of cellular immune mechanisms in various clinical situations. The precise estimation of quantitative amounts of MIF by sensitive immunochemical techniques could gain new insights into the pathogenesis of a number of clinical disorders. In addition, the exact detection of quantitative amounts of MIF in body fluids could have prognostic value.
References
Al-Askari, S., Lawrence, H. S.: In Vitro studies on transplantation immunity. II. The migration inhibition in homograft reactions in guinea pigs. Cell. Immunol.6, 292–299 (1973)
Baron, S., Levy, H. B.: Interferon. Annu. Rev. Microbiol.20, 291–318 (1966)
Block, L. H., Jaksche, H., Bamberger, S., Ruhenstroth-Bauer, G.: Human migration inhibitory factor: Purification and immunochemical characterization. J. Exp. Med.147, 541–553 (1978)
Block, L.H., Jaksche, H., Bamberger, S., Ruhenstroth-Bauer, G.: Identity of specific macrophage-active human lymphokines. LancetI, 718–719 (1978)
Block, L. H., Aloni, B., Biemesderfer, D., Kashgarian, M., Bitensky, M.W.: Macrophage migration inhibition factor: interactions with calcium, magnesium, and cyclic AMP. J. Immunol.121, 1416–1421 (1978)
Bloom, B. R., Bennett, B.: Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science153, 80 (1966)
Caspary, E.A.: Lymphocyte-antigen interaction in electrophoretic mobility test for cellular sensitization. Nature New Biol.231, 24 (1971)
Cohen, M. C., Zeschke, R., Bigazzi, P. I., Yoshida, T., Cohen, S.: Mastocytoma cell migration in vitro: Inhibition by MIF-containing supernatants. J. Immunol.114, 1641–1643 (1975)
Cohen, S.: The role of cell-mediated immunity in the induction of inflammatory responses. Am. J. Pathol.88, 502–528 (1977)
Cohen, S., Fischer, B., Yoshida, T., Bettigole, R.E.: Serum migration-inhibitory activity in patients with lymphoproliferative diseases. N. Eng. J. Med.290, 882–886 (1974)
David, J.R.: Delayed hypersensitivity in vitro: Its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc. Natl. Acad. Sci. USA56, 72 (1966)
David, J.R.: Suppression of delayed hypersensitivity in vitro by inhibition of protein synthesis. J. Exp. Med.122, 1125–1133 (1965)
David, J.R., David, R.R.: Cellular hypersensitivity and immunity. Prog. Allergy.16, 300–449 (1972)
Dumonde, D.C., Wolstencroft, R. A., Panayi, G.S., Mathew, M., Morley, J., Howson, W.T.: Lymphokines. Non-antibody mediators of cellular immunity generated by lymphocyte activation. Nature224, 38 (1969)
Feinstone, S.M., Beachey, E.H., Rytel, M.W.: Induction of delayed hypersensitivity to influenza and mumps viruses in mice. J. Immunol.103, 844–849 (1969)
Forrester, J.A., Dando, P.M., Smith, W. J., Turberville, C.: Failure to confirm the macrophage elctrophoretic mobility test in cancer. Br. J. Cancer36, 537 (1977)
Fowles, R.E., Fajardo, I.M., Leibowitch, J.L., David, J.R.: The enhancement of macrophage bacteriostasis by products of activated lymphocytes. J. Exp. Med.138, 952–964 (1973)
Froland, S.S., Gaarder, P.I.: Leucocyte migration inhibition induced by IgG in rheumatoid arthritis. LancetI, 1071–1072 (1971)
George, M., Vaughan, J.H.: In vitro cell migration as a model for delayed hypersensitivity. Proc. Soc. Exp. Biol. Med.III, 514–521 (1962)
Granger, G.A., Kolb, W.P.: Lymphocyte in vitro cytotoxicity: Mechanisms of immune and non-immune small lymphocyte mediated target L-cell destruction. J. Immunol.101, 111–120 (1968)
Grenn, J.A., Cooperband, S. R., Rutskin, J.A., Kibrich, S.: Inhibition of target cell proliferation by supernatants from cultures of human peripheral lymphocytes. J. Immunol.105, 48–54 (1970)
Hammond, M.E., Roblin, R.O., Dvorak, A.M., Selvaggio, S.S., Black, P.H., Dvorak, H.F.: MIF-like activity in simian virus 40-transformed 3T3 fibroblast cultures. Science185, 955–957 (1974)
Katz, S. J., DePetz, B.H., Zaias, N.: Production of macrophage inhibitory factor by patients with leprosy. Arch. Dermatol.103, 358–361 (1971)
Kolb, W.P., Granger, G.A.: Lymphocyte in vitro cytotoxicity: Characterization of human lymphotoxin. Proc. Natl. Acad. Sci. USA61, 1250–1255 (1968)
Kotkes, P., Pick, E.: Studies on the inhibition of macrophage migration induced by soluble antigen-antibody complexes. Clin. Exp. Immunol.19, 105–120 (1975)
Kronman, B.S., Wepsie, H.T., Churchill, H.W., Zbar, B., Boros, T., Rapp, H. J.: Tumor specific antigens detected by inhibition of macrophage migration. Science165, 296–297 (1969)
Landolfo, S., Herberman, R.B., Holden, H.T.: Two mechanisms of migration inhibition factor induction by tumor antigens. Nature270, 62–64 (1978)
Losenkua, S., Dray, S., Gotoff, S.P.: Macrophage aggregation in vitro: a correlate of delayed hypersensitivity. J. Immunol.104, 296–304 (1970)
Lawrence, H.S.: Transfer factor. Adv. Immunol.11, 195–266 (1969)
Meyer-Rienecker, H., Jenssen, H.L., Köhler, H., Günther, J., Gundlach, H. J.: Zur Anwendung und Bedeutung des Makrophagen-Elektrophorese-Mobilitäts-(MEM)-Testes bei neurologischen Erkrankungen. Klin. Wochenschr.52, 288–292 (1974)
Nathan, C.F., Karnovsky, M. L., David, J. R.: Alterations of macrophage functions by mediators from lymphocytes. J. Exp. Med.133, 1356–1376 (1971)
Nathan, C. F., Remold, H. G., David, J. R.: Characterization of a lymphocyte factor which alters macrophage functions. J. Exp. Med.137, 275–290 (1973)
Newman, W., Gordon, S., Haemmerling, U., Senik, H., Bloom, B.: Production of migration inhibition factor (MIF) and an inducer of plasminogen activator (IPA) by subsets of T-cells in MLC. J. Immunol.3, 927 (1978)
Pick, R., Brostoff, J., Krejci, J., Turk, J. L.: Interaction between sensitized lymphocytes and antigen in vitro. II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors. Cell Immunol.1, 92–109 (1970)
Pick, E.: Cyclic AMP affects macrophage migration. Nature New Biol.238, 176–177 (1972)
Pick, E., Manheimer, S.: The mechanism of action of soluble lymphocytic mediators. Cell. Immunol.11, 30–46 (1974)
Pick, E., Abrahamer, H.: Blocking of macrophage migration inhibitory factor action by microtubular disruptive drugs. Int. Arch. Allergy Appl. Immunol.44, 325–220 (1973)
Piessens, W. F., Churchill, W.H., David, J. R.: Nonspecific tumor killing by macrophages activated in vitro with lymphocyte mediators. Fed. Proc.33, 781 (Abstr.) (1974)
Preece, A. W., Light, P. A.: The macrophage electrophoretic mobility (MEM) test for malignant disease. Clin. Exp. Immunol.18, 543–552 (1974)
Remold, H. G.: Requirement for α-L-fucose on the macrophage membrane receptor for MIF. J. Exp. Med.138, 1065–1076 (1973)
Rich, A. R., Lewis, M. R.: The nature of allergy in tuberculosis as revealed by tissue culture studies. Bull. Johns Hopk. Hosp.50, 115 (1932)
Rocklin, R. E.: Products of activated lymphocytes: leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF). J. Immunol.112, 1461–1466 (1974)
Rocklin, R. E.: Histamine-induced suppressor factor (HSF): Effect on migration inhibitory factor (MIF) production and proliferation. J. Immunol.118, 1734–1738 (1977)
Rocklin, R. E., Remold, H. G., David, J. R.: Characterization of human migration inhibitory factor (MIF) from antigen-stimulated lymphocytes. Cell. Immunol.5, 436–445 (1972)
Rocklin, R. E.: Clinical Application of in vitro lymphocyte tests. Prog. Clin. Immunol.2, 21–67 (1974)
Rocklin, R. E., David, J.: Detection in vitro of cellular hypersensitivity to drugs. J. Allergy Clin. Immunol.48, 276–282 (1971)
Rocklin, R. E., Chilgren, R. A., Hong, R., David, J. R.: Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro. Cell. Immunol.1, 290–299 (1070)
Rocklin, R. E., Sheremata, W. A., Feldman, R. G., Kies, M. W., David, J. R.: The Guillain-Barre syndrome and multiple sclerosis: In vitro cellular responses to nervous-tissue antigens. N. Engl. J. Med.284, 803–808 (1971)
Rosenthal, A. S., Lipsky, P.E., Shevach, E. M.: Macrophage-lymphocyte interaction and antigen recognition. Fed. Proc.34, 1734–1748 (1975)
Rovensky, J., Svejcar, J., Perarek, J., Zitnan, D., Hajzok, O., Cebecauer, L.: Correlation between the results of the migration inhibitory factor production test with DNA and the severity of the disease in the systemic lupus erythematosus patients. Z. Immunitätsforsch.150, 24–30 (1975)
Seaman, G.V.F., Cook, G.M.W.: Cell Electrophoresis. Ambrose, E. J. (ed.), p. 48. London: J. and A. Churchill 1965
Tautz, Chr., Schneider, W., Laier, E., Brügmann, G.: Der Elektrophoretische-Mobilitäts-(EM-)Test: Untersuchungsmethode zur Unterscheidung von malignen und nicht malignen Tumoren. Klin. Wochenschr.56, 175–186 (1978)
Topilsky, M., Siltzbach, L. E., Williams, M., Glade, P. R.: Lymphocyte response in sarcoidosis. LancetI, 117–120 (1972)
Valentine, R.T., Lawrence, H. S.: Lymphocyte stimulation: transfer of cellular hypersensitivity to antigen in vitro. Science165, 1014–1016 (1969)
Ward, P. A., Offen, C. D., Montgomery, J. R.: Chemoattractants of leukocytes with special preference to lymphocytes. Fed. Proc.30, 1721–1724 (1971)
Whitcomb, M. E., Rocklin, R. E.: Transfer factor therapy in a patient with progressive primary tuberculosis. Ann. Intern. Med.79, 161–166 (1973)
Yoshida, T., Edelson, R., Cohen, S., Green, I.: Migration inhibitory activity in serum and cell supernatants in patients with Sezary Syndrome. J. Immunol.114, 915–918 (1975)
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Block, L.H., Ruhenstroth-Bauer, G. Biological and clinical relevance of human macrophage migration inhibitory factor (MIF). Blut 38, 93–101 (1979). https://doi.org/10.1007/BF01007950
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DOI: https://doi.org/10.1007/BF01007950
Schlüsselwörter
- Lymphokine
- Makrophagen-Migrationshemmfaktor (MIF)
- Biochemische Parameter
- Biologische Funktion
- Klinische Bedeutung