Blut

, Volume 37, Issue 6, pp 313–317 | Cite as

Evaluation of non-stimulated nitroblue-tetrazolium test in patients with malignant lymphomas

  • V. Liso
  • G. Specchia
  • G. Troccoli
Original Works
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Summary

The NBT-test was performed in 54 patients with Hodgkin and nonHodgkin lymphoma showing no bacterial infection exept for one case. 18 patients presented, at onset of the disease, a number of neutrophilic NBT-reducing granulocytes at pathological levels (> 12%).

In order to evaluate the influence of cytostatic drugs on NBT-test serial blood samples were taken during polychemotherapy in 17 patients with lymphoma. In our experience, cytostatics (COPP) do not necessarily lessen NBT-reducing activity of granulocytes.

The results suggest that the NBT in malignant lymphomas could not be used as an indication of bacterial infection.

Key words

NBT-test Malignant lymphomas 

Die Bewertung des NBT-Testes bei malignen Lymphomen

Zusammenfassung

Der Nitroblau-Tetrazolium-Test (NBT) wurde bei 54 Patienten mit malignen Lymphomen durchgeführt. Diese Patienten hatten mit einer Ausnahme keine erkennbaren Infektionen. Bei 18 Patienten war vorder Erkrankung die Zahl der NBT-reduzierenden Granulozyten über die Norm erhöht.

Verlaufsuntersuchungen wÄhrend einer Polychemotherapie bei 17 Patienten zeigten, da\ die Zytostatika-Therapie als solche die Zahl der NBT-reduzierten Granulozyten nicht vermindert.

Die Ergebnisse zeigen, da\ der NBT-Test bei malignen Lyphomen zum Nachweis bakterieller Infektionen nicht geeignet ist.

Schlüsselwörter

NBT-Test Maligne Lymphome 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • V. Liso
    • 1
  • G. Specchia
    • 1
  • G. Troccoli
    • 1
  1. 1.Istituto di Clinica Medica II, Sez. EmatologiaUniversitá di BariBariItaly

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