Zusammenfassung
Bei einem Patienten mit leukÄmischer Form eines Lymphosarkoms wurden mehrere Membranmarker untersucht. Der Nachweis von monoklonalem Membranimmunglobulin vom IgM-kappa-Typ, welches in hoher Dichte von den Zellen gebildet wurde, erbrachte die eindeutige Zuordnung der malignen Zellen zur B-Zellreihe. Interessanterweise waren weder Fcnoch C3d-Rezeptoren nachweisbar. Das Fehlen einer Rosettenbildung mit MÄuseerythrozyten war ein zusÄtzliches Unterscheidungsmerkmal zur chronisch lymphatischen LeukÄmie vom B-Zelltyp. Der immunologische PhÄnotyp der LeukÄmiezellen wird in Zusammenhang mit B-Lymphozyten geringeren Differenzierungsgrades diskutiert.
Summary
Various cell surface markers were studied in a patient with lymphosarcoma cell leukemia. The B-cell derived feature of the neoplastic cells could be identified by demonstration of monoclonal surface immunoglobulin of IgM-kappa type of high density synthesized by the cells. Interestingly, there were no Fc-nor C3d-receptors demonstrable using various techniques. Only 22 % of the leukemic cells expressed C3b receptors. The failure of rosette formation with mouse erythrocytes was an additional surface feature distinguishing from ordinary chronic lymphatic leukemia of the B cell type. The phenotype of the leukemia cells is discussed as corresponding to that of a less differentiated B lymphocyte.
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Unterstützt von der Deutschen Forschungsgemeinschaft (Th 229/2). Studie im Rahmen des Assoziationsvertrages Euratom/GSF Nr. 217-76-1 BIOD
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Thiel, E. B-cell lymphoma lacking Fc-and C3d-receptors. Blut 37, 307–312 (1978). https://doi.org/10.1007/BF01007865
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DOI: https://doi.org/10.1007/BF01007865