Summary
The growth of mononuclear human peripheral blood cells from five patients with aplastic anemia (AA) was tested in diffusion chambers over a period of 13 days. Considerable differences were seen in the total cell number compared with controls. The total cell number of three patients with AA was markedly lower than in the control group (eight controls). The differentiation of the cells showed considerable differences in the growth patterns of the lymphocytes and in granulopoiesis; in three of five patients with AA no granulopoiesis was observed.
Zusammenfassung
Das Wachstum mononukleärer Zellen des peripheren Blutes von fünf Patienten mit aplastischer Anämie (AA) wurde über einen Zeitraum von 13 Tagen mittels der Diffusionskammerkultur untersucht. Deutliche Unterschiede zeigten sich beim Vergleich der Gesamtzellzahl während der Kulturperiode. Die Gesamtzellzahlen von drei Patienten mit aplastischer Anämie lagen wesentlich unter der Vergleichsgruppe (acht Normalpersonen). Bei der Differenzierung ergaben sich deutliche Abweichungen im Wachstumsmuster der Lymphozyten, besonders aber der Granulopoese, die bei drei Patienten mit AA im Beobachtungszeitraum nicht nachweisbar war.
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Böning, L., Lau, B. & Wilmanns, W. Kultur mononukleärer Blutzellen von Patienten mit aplastischer Anämie in der Diffusionskammer. Blut 41, 445–450 (1980). https://doi.org/10.1007/BF01007769
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DOI: https://doi.org/10.1007/BF01007769