Zusammenfassung
In 33 Blutproben von gesunden weiblichen und männlichen Versuchspersonen zeigt die Erythrozytenzahl bei Vergrößerung des mittleren Zellvolumens einen statistisch signifikanten nichtlinearen Abfall. Aus hämatologischen Daten der Literatur wurde eine bei 20 anderen Säugern gleiche und ebenfalls statistisch signifikante Beziehung gefunden. Es handelt sich dabei um eine hyperbolische Beziehung zwischen dem mittleren Zellvolumen und der Erythrozytenzahl, worin das Zellvolumen die unabhängige Veränderliche sein dürfte.
Summary
In 33 male and female human blood samples, red cell count decreased in a highly significant (p <0.01) non-linear fashion as MCV increased. An identical, equally significant relationship was obtained using published hématologie values for 20 other mammalian species. These findings suggest a hyperbolic relationship between RCC and MCV, with the latter as the independent variable.
This is a preview of subscription content, log in via an institution to check access.
References
Adamson JW, Finch CA (1975) Hemoglobin function, oxygen affinity, and erythropoietin. Ann Rev Physiol 37: 351–369
Burton AC (1969) The mechanics of the red cell in relation to its carrier function. In: Wolstenholme GEW, Knight J (eds) Circulatory and Respiratory Mass Transport. Little and Brown, Boston, pp 67–84
Chalmers DM, Levi AJ, Chanarin I, North WRS, Meade TW (1979) Mean cell volume in a working population: The effects of age, smoking, alcohol, and oral contraception. Br J. Haematol 43: 631–636
Chien S, Usami S, Dellenback RJ, Bryant CA (1971) Comparative hemorheology-hematological implications of species differences in blood viscosity. Biorheology 8: 35–57
Chien S (1972) Present state of blood rheology. In: Messmer K, Schmid-Schönbein H (eds) Hemodilution. Theoretical basis and clinical application. Karger, Basel, pp 1–45
Dittmer DS (ed) (1961) Blood and other body fluids. Federation of American Societies for Experimental Biology, Washington, DC, p 116
Edwards AL (1962) Statistical methods for the behavioral sciences. Holt, Rinehart and Winston, New York
Finch CA, Lenfant C (1972) Oxygen transport in man. New Engl J Med 286: 407–415
Graber SE, Krantz SB (1978) Erythropoietin and the control of red cell production. Ann Rev Med 29: 51–66
Lovlin RE, Sewchand LS, Beck JS, Rowlands S (1979) Human erythrocyte volume is linearly related to cell concentration in blood. Blut 38: 361–363
Lovlin RE, Sewchand LS, Beck JS, Rademaker AW, Rowlands S (1979) Erythrocyte volume and count: A linear relation descriptive of population differences. Scand J Haematol 22: 197–204
Miale JB (1977) Laboratory medicine. Hematology. chapt 1. C. V. Mosby, S. Louis
Papayannopoulou T, Finch CA (1972) On the in vivo action of erythropoietin: A quantitative analysis. J Clin Invest 51: 1179–1185
Riggs DS (1963) The mathematical approach to physiological problems. Williams and Wilkins, Baltimore
Stone HO, Thompson HK Jr, Schmidt-Nielsen K (1968) Influence of erythrocytes on blood viscosity. Am J Physiol 214: 913–918
Sullivan SF (1972) Oxygen transport. Anesthesiology 37: 140–147
Withers PC, Casey TM, Casey KK (1979) Allometry of respiratory and haematological parameters of arctic mammals. Comp Biochem Physiol 64A: 343–350
Author information
Authors and Affiliations
Additional information
This study was supported by grants AM20829 and HL22123 from the National Institutes of Health
Rights and permissions
About this article
Cite this article
Norton, J.M., Rand, P.W. A relationship between erythrocyte volume and concentration in humans and other mammals. Blut 41, 421–426 (1980). https://doi.org/10.1007/BF01007766
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01007766