Blut

, Volume 37, Issue 1, pp 37–41 | Cite as

Problems in the detection of carriers of hemophilia A: the influence of stress and thrombin

  • U. Göbel
  • R. von Kries
  • H. Jürgens
  • H. von Voss
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  • 15 Downloads

Summary

After exposure to stress, factor VIII coagulant activity and factor VIII antigen were determined in healthy volunteers for about 3 days. Three out of four volunteers at different times showed results resembling a carrier state.

In vitro incubation of plasma with thrombin in decreasing concentrations showed increased factor VIII coagulant activity, although no fibrin clot or fibrin monomers were formed. The concentration of factor VIII antigen remained constant. The action of thrombin can explain the misclassification of known carriers.

Key words

Haemophilia A Factor VIII and stress Factor VIII and thrombin Detection of carrier state 

Zur Problematik des Konduktorinnen-Nachweises bei der Hämophilie A: der Einfluß von Streß und Thrombin

Zusammenfassung

Gesunde Versuchspersonen wurden einem definierten Streß ausgesetzt und anschließend über einen Zeitraum von 3 Tagen Faktor VIII Gerinnungsaktivität und Faktor VIII Antigen bestimmt. Zu verschiedenen Zeitpunkten zeigten 3 der insgesamt 4 Versuchspersonen Ergebnisse, die einen Konduktorinnenstatus vermuten ließen.

In-vitro-Inkubation von Plasma mit Thrombin in abnehmenden Konzentrationen zeigte einen Anstieg der Faktor VIII Gerinnungsaktivität ohne Bildung von Fibringerinnseln oder Fibrinmonomeren. Die Konzentration des Faktor VIII blieb unverändert. Die Thrombinwirkung kann die Fehlbeurteilung von sicheren Konduktorinnen erklären.

Schlüsselwörter

Hämophilie A Faktor VIII und Streß Faktor VIII und Thrombin Nachweis des Konduktorstatus 

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Copyright information

© Springer Verlag 1987

Authors and Affiliations

  • U. Göbel
    • 1
  • R. von Kries
    • 1
  • H. Jürgens
    • 1
  • H. von Voss
    • 1
  1. 1.Kinderklinik II der Universität DüsseldorfDüsseldorfFederal Republic of Germany

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