Abstract
The synthesis of total cellular as well as acid-soluble nuclear proteins and estrogen receptor is high in the uteri of young (22 weeks) and decreases to half in old (104 weeks) rats. Administration of estrogen induces the synthesis of these proteins significantly in young but shows no remarkable effect in old rats. Interestingly, a specific cytosolic protein of 45 kDa is stimulated about two-fold after estrogen injection in young but not in old rats. These findings further establish the reduced responsiveness of uterus to estrogen in old age.
Similar content being viewed by others
References
Rories C & Spelsberg TC (1989) Ann Rev. Physiol. 51: 653–681
Murdoch FE & Gorski J (1991) Mol. Cell. Endocrinol. 78: C103-C108
Iacobelli S, Marchetti P, Bartoccioni E, Natoli V, Cambia G & Kaye AM (1981) Mol. Cell. Endocrinol. 21: 321–331
Thakur MK (1988) Mech. Ageing Dev. 45: 93–110
Guo JZ & Gorski J (1988) Mol. Endocrinol. 2: 686–692
Notides A & Gorski J (1966) Proc. Natl. Acad. Sci. USA 56: 230–235
Reiss NA & Kaye AM (1981) J. Biol. Chem. 256: 5741–5743
Pavlik EJ & Coulson PB (1976) J. Steroid Biochem. 7: 1–6
Richardson A (1981) Biological Mechanism in Aging (Schimke, R.T. ed.) Washington, D.C., U.S. Government Printing Office, pp. 339–358
Kanungo MS, Koul O & Reddy KR (1970) Exp. Gerontol. 5: 261–269
Markrides SC (1983) Biological Rev. 58: 343–422
Webster GC (1985) In: Sohal, RS, Birnbaum, LS & Cutler, RG (Eds.) Molecular Biology of Aging:Gene Stability and Gene Expression. Raven Press, New York, pp. 263–289
Kaur J & Thakur MK (1990) Mol. Biol. Rep. 14: 261–264
Lowry OH, Rosebrough NJ, Far AL & Ranall FJ (1951) J. Biol. Chem. 193: 265–275
Laemmli UK (1970) Nature 227: 680–685
Thakur MK & Kaur J (1991) Mol. Cell. Biochem. 105: 171–177
Walker MD & Kaye AM (1981) J. Biol. Chem. 256: 23–26
Kaye AM & Reiss N (1980) In: M. Beato (Ed) Steroid Induced Uterine Proteins (pp. 3–19) Elsevier/North Holland Biomedical Press
Horigome T, Ogata F, Golding TS & Korach KS (1988) Endocrinol. 123: 2540–2548
Huang HH, Steger RW, Bruni J & Meites J (1978) Endocrinol. 103: 1835–1859
Cavallius J, Rattan SIS, Riis B & Clark BFC (1989) In: Woodhouse KW, Yelland C & James OFW (Eds) Topics in Aging Research in Europe 13: 125–132
Reff MA (1985) In: Finch CE, Schneider EL (Eds) Handbook of Biology of Aging Reinhold Company, New York
Haji M, Chuknyiska RS & Roth GS (1984). Proc. Natl. Acad. Sci. USA 81: 7481–7484
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thakur, M.K., Kaur, J. Estrogen-induced synthesis of uterine proteins declines during aging. Mol Biol Rep 17, 29–34 (1993). https://doi.org/10.1007/BF01006397
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01006397