The Histochemical Journal

, Volume 4, Issue 4, pp 267–303 | Cite as

Theoretical and practical aspects of glutaraldehyde fixation

  • David Hopwood


This review first considers the many structures put forward for glutaraldehyde, and the purification of the commercial material for chemical, histological and histochemical studies. Some practical and theoretical problems of tissue fixation with glutaraldehyde, including artefacts, are then discussed. The chemical reactions with amino acids and proteins are considered next together with the physical changes in the proteins during the reactions. The known reactions of glutaraldehyde with nucleic acids, lipids and mucosubstances are explored briefly.


Lipid Nucleic Acid Glutaraldehyde Practical Aspect Physical Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Chapman and Hall Ltd 1972

Authors and Affiliations

  • David Hopwood
    • 1
  1. 1.Department of PathologyUniversity of NottinghamNottinghamUK

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