Summary
α1-Antitrypsin and α1-inhibitor-3 were localized for the first time inside skeletal muscle cells. Their content, especially that of α1-inhibitor-3, was greatly reduced following streptozotocin-induced diabetes. α1-Antitrypsin and α1-inhibitor-3 were also observed in the vascular components and interstitial space surrounding both control and diabetic soleus muscles as revealed by immunofluorescence. In diabetic muscles, the non-myofibre locale of α1-inhibitor-3 was reduced, and to a lesser extent, α1-antitrypsin. Both myofibre and extracellular patterns were reversed to control levels by insulin replacement.
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Stauber, W.T., Ong, S.H., Fritz, V.K. et al. Protease inhibitor localization in control and streptozotocin-diabetic skeletal muscles. Histochem J 15, 1079–1086 (1983). https://doi.org/10.1007/BF01003971
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DOI: https://doi.org/10.1007/BF01003971