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The Histochemical Journal

, Volume 6, Issue 5, pp 523–530 | Cite as

The effects of age and exercise on the succinic dehydrogenase content of dystrophic hamster muscle fibres

  • K. F. Howells
  • G. Goldspink
Papers

Synopsis

Groups of male dystrophic hamsters of different ages were subjected to a weightlifting and exercise regimen. Frozen sections from the biceps brachii, soleus and extensor digitorum longus muscles were incubated for succinate dehydrogenase activity. The total amount of Nitro BT diformazan deposited in individual muscle fibres was estimated microspectrophotometrically by the two-wavelength method. Similar measurements were made on muscles from dystrophic and normal control animals. Succinate dehydrogenase activity in the muscle fibres decreased throughout the course of the myopathy in the biceps brachii and soleus, the fibres of the extensor digitorum longus remaining relatively unaffected. In the young (9-week) soleus and extensor digitorum longus, exercise caused slight increases in succinate dehydrogenase activity, but in general the exercise stimulus had little effect on the activity of the dehydrogenase.

Keywords

Muscle Fibre Succinate Similar Measurement Myopathy Freeze Section 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman and Hall Ltd 1974

Authors and Affiliations

  • K. F. Howells
    • 1
  • G. Goldspink
    • 1
  1. 1.The Muscle Research LaboratoryDepartment of Zoology, The UniversityKingston-upon-HullUK

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