Naunyn-Schmiedebergs Archiv für Pharmakologie

, Volume 270, Issue 4, pp 378–391 | Cite as

The influence of adrenergic receptor-blocking agents, amphetamine, and 6-aminonicotinamide on thermoregulation

  • H. Coper
  • H. Lison
  • H. Rommelspacher
  • G. Schulze
  • S. Strauss
Article

Summary

The influence ofα- andΒ-receptor-blocking agents, as well as that of amphetamine and of 6-aminonicotinamide (6-AN) on the body temperature of the rat was examined at three different ambient temperatures (AT). The ambient temperature is crucial both for the direction and the potency of the caloric effect. The ambient temperature at which a drug does not affect the body temperature is referred to as the specific indifferent temperature. At + 4‡C and + 22–24‡C., the α-receptor blockers phentolamine, and Dihydroergotamine (DHE), as well as 6-AN lower the body temperature, while theΒ-receptor blockers D(−)INPEAandL(+)INPEA do not interfere with it. The specific indifferent temperature of amphetamine lies below 22‡C. Higher ambient temperatures result in hyperthermia, lower temperatures lead to hypothermia. The results obtained in combined treatment demonstrate that the thermic effect produced by amphetamine at + 4‡C AT probably does not develop via adrenergic mechanisms. In addition, our studies do not rule out the possibility that 6-AN may influence body temperature in a similar way as phentolamine and DHE.

Key-Words

Adrenergic Blockers Amphetamine 6-Aminonicotinamide Hyperthermia Hypothermia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Axelrod, J.: Amphetamine: Metabolism, physiological disposition, and its effects on catecholamine storage. In: E. Costa and S. Garattini (Eds.): Amphetamines, pp. 207–216. New York: Raven Press, and Amsterdam: North-Holland Publ. 1970.Google Scholar
  2. Baethmann, A., Reulen, H. J., Brendei, W.: Die Wirkung des Antimetaboliten 6-Aminonicotinamid (6-ANA) auf Wasser- und Elektrolytgehalt des Rattenhirns und ihre Hemmung durch NikotinsÄure. Z. ges. exp. Med.146, 226–240 (1968).Google Scholar
  3. Beckmann, A. L.: Effect of intrahypothalamic norepinephrine on thermoregulatory responses in the rat. Amer. J. Physiol.218, 1596–1604 (1970).Google Scholar
  4. Brodie, B. B., Cho, A. K., Gessa, G. L.: Possible role of p-hydroxynorephedrine in the depletion of norepinephrine induced by d-amphetamine and in tolerance to this drug. In: E. Costa and S. Garattini (Eds.): Amphetamines, pp. 217–230. New York: Raven Press, and Amsterdam: North-Holland Publ. 1970.Google Scholar
  5. Coper, H.: Stoffwechselstörungen durch Antimetaboliten des Nicotinamids. In: H. Frhr. v. Kress u. K.-U. Blum (Hrsg.): B-Vitamine, Klinische und physiologisch-chemische Probleme. Symp. 1. Med. Klin. FU Berlin, 30. 9.-1. 10. 1965, S. 275–291. Stuttgart: Schattauer 1966.Google Scholar
  6. Cunningham, D. I., Stolwijk, I. A., Murakami, N., Hardy, J. P.: Responses of neurones in the preoptic area to temperature, serotonin, and epinephrine. Amer. J. Physiol.213, 1570–1581 (1967).Google Scholar
  7. Dingell, J. V., Owen, M. L., Norwich, M. R., Sulser, F.: On the role of norepinephrine biosynthesis in the central action of amphetamine. Life Sci.6, 1155–1162 (1967).Google Scholar
  8. Feldberg, W., Lotti, V. I.: Temperature responses to monoamines and an inhibitor of monoaminoxidase injected into the cerebral ventricles of rats. Brit. J. Pharmacol. Chemother.31, 152–161 (1967).Google Scholar
  9. Feldberg, W., Myers, R. D.: Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulation. J. Physiol. (Lond.)173, 226–237 (1964).Google Scholar
  10. Hardy, J. D., Hellon, R. F., Sutherland, K.: Temperature-sensitive neurones in the dog's hypothalamus. J. Physiol. (Lond.)75, 242–253 (1964).Google Scholar
  11. Herken, H., Lange, K., Kolbe, H.: Brain disorders induced by pharmacological blockade of the pentose phosphate pathway. Biochem. biophys. Res. Commun.36, 93–100 (1969).Google Scholar
  12. —, Neuhoff, V.: Spektrofluorometrische Bestimmung des Einbaues von 6-AminonicotinsÄureamid in die oxydierten Pyridinnucleotide der Niere. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.247, 187–201 (1964a).Google Scholar
  13. —, Senft, G., Zemisch, B.: Die EinschrÄnkung des tubulÄren Natrium- und Kaliumtransportes durch Biosynthese 6-AminonicotinsÄureamid enthaltender Nucleotide. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.249, 54–70 (1964b).Google Scholar
  14. ———: Der Einflu\ von 6-AminonicotinsÄureamid auf die Verteilung der Natrium- und Kaliumionen zwischen dem extra- und intracellulÄren Raum in der Leber und der Skeletmuskulatur. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.253, 364–371 (1966).Google Scholar
  15. Jaques, R., Bein, H. J., Meier, R.: Serotonin antagonists, with special reference to the importance of sympathomimetic amines and isopropyl-noradrenaline. Helv. physiol. pharmacol. Acta14, 269–279 (1956).Google Scholar
  16. Johnson, H. D., Green, H. D., Lanier, J. T.: Comparison of adrenergic blocking action of Ilidar, Regitine, and Priscoline in the innervated saphenous arterial bed (skin exclusive of muscle) and fermoral arterial bed (muscle exclusive of skin) of the anesthetized dog. J. Pharmacol. exp. Ther.108, 144–157 (1953).Google Scholar
  17. Lange, K., Kolbe, H., Keller, K., Herken, H.: Der Kohlenhydratstoffwechsel des Gehirns nach Blockade des Pentose-Phosphat-Weges durch 6-AminonicotinsÄureamid. Hoppe-Seyler's Z. physiol. Chem.351, 1241–1252 (1970).Google Scholar
  18. Lessin, A. W., Parkes, M. W.: The hypothermic and sedative act on of reserpine in the mouse. J. Pharm. Pharmacol.9, 657–662 (1957).Google Scholar
  19. Lison, H.: Untersuchungen zur Differenzierung zentralnervöser Funktionsstörungen durch einen Antimetaboliten des Nicotinamids. Inaug.-Diss., Med. FakultÄt, Freie Univ. Berlin 1969.Google Scholar
  20. - Rommelspacher, H., Schulze, G. W., Strauss, S. M.: On the relationship of monoamine concentrations in the brain and the body temperature of the rat. In preparation (1971).Google Scholar
  21. Lomax, P., Foster, R. S., Kirkpatrick, W. E.: Thermoregulation in the rat: Interactions of cholinergic and adrenergic agents in the hypothalamus. Proc. West. Pharmacol. Soc.11, 48–51 (1968).Google Scholar
  22. Myers, R. D.: Discussion of serotonin, norepinephrine and fever. In: S. Garattini and P. A. Shore (Eds.): Advances in Pharmacology, Vol. 6, Part A: Biochemistry, Localization and Physiology, pp. 318–321. New York-London: Academic Press 1968.Google Scholar
  23. —: Temperature regulation: Neurochemical systems in the hypothalamus. In: W. Haymaker, E. Anderson and W. J. H. Nauta (Eds.): The Hypothalamus, pp. 506–523. Springfield: Ch. C. Thomas 1969.Google Scholar
  24. Nakayama, T., Eisenman, J., Hardy, J. D.: Single unit activity of anterior hypothalamus during local heating. Science134, 560–561 (1961).Google Scholar
  25. Pathil, P. N., Lapidus, I. B., Tye, A.: Steric aspects of adrenergic drugs. J. Pharmaceut. Sci.59, 1205–1234 (1970).Google Scholar
  26. Persson, T., Waldeck, B.: Is there an interaction between dopamine and noradrenaline containing neurons in the brain? Acta physiol. scand.78, 142–144 (1970).Google Scholar
  27. Shemano, I., Nickerson, M.: Mechanisms of thermal responses of pentylenetetrazol. J. Pharmacol. exp. Ther.126, 143–147 (1959).Google Scholar
  28. Weber, E.: Grundri\ der Biologischen Statistik. Jena: VEB Fischer1961.Google Scholar
  29. Weissman, A., Koe, B. K., Tenen, St. S.: Antiamphetamine effects following inhibition of tyrosine hydroxylase. J. Pharmacol, exp. Ther.151, 339–532 (1966).Google Scholar
  30. Wiederholt, M., Hierholzer, K., Senft, G., Herken, H.: Lokalisation der natriuretischen Wirkung von 6-Aminonicotinamid in der Rattenniere. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path.261, 143–151 (1968).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • H. Coper
    • 1
  • H. Lison
    • 1
  • H. Rommelspacher
    • 1
  • G. Schulze
    • 1
  • S. Strauss
    • 1
  1. 1.Institut für Neuropsychopharmakologie der Freien UniversitÄt BerlinDeutschland

Personalised recommendations