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Graft-versus-Host-Reaktion nach Granulozytentransfusion von einem Normalspender

Graft-versus-Host reaction following granulocyte transfusion from a normal donor

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Summary

Graft-versus-Host disease following the transfusion of leukocytes from normal donor occured during remission-reinduction therapy in a 5 years old girl with acute lymphocytic leukemia. The clinical picture consisting of rash, diarrhea and somnolence was congruent with the diagnosis. Graft-versus-Host disease was confirmed by histology of skin biopsy and exclusion of other causes. The child survived the disease. We recommend the irradiation of leukocyte concentrates before transfusion.

Zusammenfassung

Die Arbeit berichtet von einem 5 Jahre alten Mädchen mit akuter lymphatischer Leukämie, das nach Transfusion von 2 Granulozytenkonzentraten das klinische Bild einer Graft-versus-Host-Reaktion zeigte. Die Diagnose stützt sich auf den histologischen Befund der Hautbiopsie sowie auf den Ausschluß anderer Erkrankungen ähnlicher klinischer Erscheinung. Wir halten die Bestrahlung von Granulozytenkonzentraten auf Grund dieser Beobachtungen für notwendig.

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Salfner, B., Borberg, H., Krüger, G. et al. Graft-versus-Host-Reaktion nach Granulozytentransfusion von einem Normalspender. Blut 36, 27–34 (1978). https://doi.org/10.1007/BF01002117

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  • DOI: https://doi.org/10.1007/BF01002117

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