, Volume 36, Issue 6, pp 363–369 | Cite as

T-Zell-Antigen positive, E-Rosetten negative akute Lymphoblastenleukämie

  • E. Thiel
  • H. Rodt
  • B. Netzel
  • D. Huhn
  • G. F. Wündisch
  • R. J. Haas
  • Ch. Bender-Götze
  • S. Thierfelder

T-cell-antigen positive, E-rosette negative acute lymphoblastic leukaemia


The lymphoblasts from 100 patients with acute lymphocytic leukaemia were investigated for the expression of receptors for sheep erythrocytes (E) and of a specific heterologous T cell antigen (T). In 17 cases, both T cell markers were expressed simultaneously on the leukaemic cells. In 13 cases only T antigens could be demonstrated on the lymphoblasts. A quantitative analysis of T antigens by immunoautoradiography revealed that the T expression of ET+-lymphoblasts was in general like that of E+T+-lymphocytes in the blood of normal persons, in several cases even higher. Therefore, the failure of E-rosette formation cannot be correlated to a decrease of the other T cell differentiation marker. In 7 out of 9 tested cases, a strong acid phosphatase reaction product located paranuclearly could be demonstrated. Complement-receptors were expressed in 3 of 5 cases which were also demonstrated in some cases of the E+T+-ALL group. The latter group was characterized by a T antigen expression like that of thymocytes. 4 cases of the ET+ALL group were adults. Since the leukaemia cells of 2 cases were negative for acid phosphatase, PAS and all surface markers including cALL antigen, the T antigen can classify undifferentiated and otherwise unclassificable leukaemias. The clinical significance of the ET+-ALL seems to be important since 5 out of 9 children with this type of ALL died soon after diagnosis.

Key words

Acute lymphatic leukaemia T cell antigen E-receptor C3-receptor Acute undifferentiated leukaemia 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • E. Thiel
    • 1
  • H. Rodt
    • 1
  • B. Netzel
    • 1
  • D. Huhn
    • 2
  • G. F. Wündisch
    • 3
  • R. J. Haas
    • 4
  • Ch. Bender-Götze
    • 5
  • S. Thierfelder
    • 1
  1. 1.Abteilung Immunologie des Instituts für HämatologieGSF MünchenMünchen 2
  2. 2.Medizinische Klinik III der Universität MünchenMünchen
  3. 3.Kinderklinik Schwabing der Technischen Universität MünchenMünchen
  4. 4.v. Hauner'sche Kinderklinik der Universität MünchenMünchen
  5. 5.Kinderpoliklinik der Universität MünchenMünchen

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