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Adjuvante Chemotherapie des osteogenen Sarkoms mit High-Dose Methotrexat/Leucovorin: Biochemische Effekte auf die DNA-Synthese der Knochenmarkzellen

High-dose Methotrexate/Leucovorin adjuvant chemotherapy of osteogenic sarcoma: Biochemical effects in DNA-synthesis of bone marrow cells

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Summary

DNA metabolism in bone marrow cells was measured under highdose Methotrexate/Leucovorin adjuvant chemotherapy of a patient with primary amputation of his right leg because of osteogenic sarcoma. The biochemical data showed that there was no rescue effect of Leucovorin after 200 mg/ kg Methotrexate. Corresponding to this “biochemical failure” of the rescue effect the patient died from the complications of a long and very severe bone marrow suppression. To improve the safety of this therapeutic regimen theintravenous injection and in some cases a higher dose of Leucovorin is recommended.

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Authors and Affiliations

  1. Klinikum Großhadern, Medizinische Klinik III, Ludwig-Maximilians-Universität München, Marchioninistraße 15, D-8000, München 70

    H. Sauer & W. Wilmanns

  2. Abteilung Klinische Hämatologie der Gesellschaft für Strahlen- und Umweltforschung München, Institut für Hämatologie, D-8000, München

    H. Sauer & W. Wilmanns

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  1. H. Sauer
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  2. W. Wilmanns
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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft (Forschergruppe „Leukämie- und Tumortherapie“)

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Sauer, H., Wilmanns, W. Adjuvante Chemotherapie des osteogenen Sarkoms mit High-Dose Methotrexat/Leucovorin: Biochemische Effekte auf die DNA-Synthese der Knochenmarkzellen. Blut 36, 357–361 (1978). https://doi.org/10.1007/BF01000594

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  • DOI: https://doi.org/10.1007/BF01000594

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