Summary
In two patients with acute leukaemia, the development of progressive interstitial pulmonary fibrosis was observed following chemotherapy with BCNU, Cytoxan and Ara-C. The x-ray changes were accompanied by restrictive changes of pulmonary function and, later on, by severe hypoxia. Serologic tests did not reveal infection with cytomegaly virus or mycoplasma pneumoniae.
These findings, together with reports in the literature, suggest a toxic effect of BCNU on the lung. The combination with Cyclophosphamide may contribute to this toxic reaction.
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Literatur
Cohen, S.M., Greenspan, E.M., Weiner, M.J., Karakow, B.: Triple combination chemotherapy of disseminated melanoma. Cancer29, 1489 (1972)
Kleeberg, U.R., Schreml, W.: Polychemotherapie des metastasierenden Melanoms: Vincristin, Carmustin und Dacarbazin. Dtsch. med. Wschr.101, 890 (1976)
Manaster, J., Cowan, D.H., Curtis, J.E., Hasselback, R., Bergsagel, E.E.: Remission maintenance of acute nonlymphoblastic leukemia with BCNU (NSC-409962) and Cyclophosphamide (NSC-26271). Cancer Chemoth. Rep.59, 537 (1975)
Rosenow III, E.C.: The spectrum of drug-induced pulmonary disease. Ann. Int. Med.77, 977 (1972)
Holoye, P.Y., Jenkius, D.E., Greenberg, S.D.: Pulmonary toxicity in long-term administration of BCNU. Cancer Treat. Rep.60, 1691 (1976)
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Schreml, W., Bargon, G., Anger, B. et al. Progrediente Lungenfibrose unter Kombinationstherapie mit BCNU. Blut 36, 353–356 (1978). https://doi.org/10.1007/BF01000593
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DOI: https://doi.org/10.1007/BF01000593