Neurochemical Research

, Volume 12, Issue 6, pp 537–540 | Cite as

Vanadate inhibition of rat cerebral cortex Na+, K+-ATPase during postnatal development

  • Jaroslava Folbergrová
  • Pavel Mareš
Original Articles


The Na+, K+-ATPase activity and its response to vanadate inhibition was investigated in cerebral cortex homogenates of 7-, 12- and 18-day-old rats. The enzyme was inhibited by vanadate in a dose-dependent manner in all these age groups. Furthermore, there was a different sensitivity towards vanadate during postnatal development; the concentration of V+5 needed for 50% inhibiton of Na+, K+-ATPase was 1.1×10−6M, 2×10−7M and 4.4×10−7M for 7-, 12- and 18-day-old rats, respectively. It is suggested that the different sensitivity of Na+, K+-ATPase towards vanadate inhibition during postnatal development might be due to age-dependent changes in the ratio of various cell types.

Key Words

Brain development Na+, K+-ATPase vanadate 


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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Jaroslava Folbergrová
    • 1
  • Pavel Mareš
    • 1
  1. 1.Institute of PhysiologyCzechoslovak Academy of SciencesPrague 4Czechoslovakia

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