Blut

, Volume 32, Issue 1, pp 21–28 | Cite as

Surface immunoglobulins and receptor sites for aggregated IgG on leukemic reticuloendotheliosis cells

  • Christoph Huber
  • Hans Asamer
  • Gert Michlmayr
  • Herbert Braunsteiner
Originalarbeiten

Summary

On blood lymph nodes and spleen cells of 4 patients with leukemic reticuloendotheliosis (LR) the binding of125J-labelled IgG aggregates as well as binding of125J-labelled anti immunoglobulin sera was studied. Moreover the capacity to form spontaneous rosettes with sheep red blood cells to bind immune complement complexes as well as the proliferative response in the presence of PHA were investigated.

On the surface of hairy cells a variety of immunoglobulins were demonstrable. IgG of both types was found to be the predominant surface bound immunoglobulin and evidence was obtained, that these antibodies were adsorbed from the serum via Fc-receptors. In all LR-cases the percentages of T-cell rosettes as well as the PHA responses were decreased when compared with the normal controls. The numbers of immune complement complex binding cells were in the range of the normal controls. Results are discussed with respect to the origin of hairy cells in LR.

Keywords

Normal Control Spleen Cell Proliferative Response Receptor Site Binding Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

An Blut-Lymphknoten und Milzzellen von 4 Patienten mit leukämischer Retikuloendotheliose (LR) wurde die Bindung125J-markierter IgG-Aggregate sowie von125J-markierten monospezifischen und polyvalenten Antiimmunglobulin-Serenuntersucht. Ferner wurde die Fähigkeit dieser Zellen zur spontanen Rosettenbildung mit Schaferythrozyten zur Bindung von Immun-Komplement-Komplexen sowie der proliferative Respons in Gegenwart von PHA getestet.

An der Oberfläche von Haarzellen wurde eine Vielfalt von Immunglobulinen nachgewiesen. IgG beider Typen war das vorherrschende Immunglobulin, und Hinweise wurden erhalten, daß dieser Antikörper aus dem Serum durch Fc-Rezeptoren absorbiert wird. In allen Fällen von LR war der Prozentsatz von T-Zell-Rosetten ebenso wie der PHA-Respons gegenüber den Normalen vermindert. Der Anteil Immun-Komplement-Komplex bindender Lymphozyten war dagegen im Normbereich gelegen. Die Ergebnisse werden im Hinblick auf die Herkunft der Haarzellen bei LR besprochen.

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Christoph Huber
    • 1
  • Hans Asamer
    • 1
  • Gert Michlmayr
    • 1
  • Herbert Braunsteiner
    • 1
  1. 1.Department of Internal MedicineUniversity of InnsbruckDeutschland

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