Neurochemical Research

, Volume 14, Issue 4, pp 367–370 | Cite as

Effects of palmitate on astrocyte amino acid contents

  • Marc Yudkoff
  • Itzhak Nissim
  • Ilana Nissim
  • Janet Stern
  • David Pleasure
Original Articles


The effects of palmitate on intracellular and extracellular amino acid concentrations of cultured astrocytes was studied. Exposure of astrocytes to either 0.72 mM or 0.36 mM palmitate was associated with a significant reduction in the intracellular pool of glutamine and taurine. In contrast, the intracellular concentration of histidine, glycine, citrulline, isoleucine and leucine were increased in the presence of 0.72 mM palmitate. Comparable changes in the extracellular amino acid pool were not observed. The data suggest that palmitic acid, which accumulates in the brain during periods of anoxia, alters the metabolism of several amino acids in cultured astrocytes. These changes may be of significance in terms of the pathophysiology of a stress such as anoxia.

Key Words

Palmitate amino acids astrocytes anoxia 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Marc Yudkoff
    • 1
  • Itzhak Nissim
    • 1
  • Ilana Nissim
    • 1
  • Janet Stern
    • 2
  • David Pleasure
    • 2
  1. 1.Divisions of Metabolism and Experimental NeurologyUniversity of Pennsylvania School of MedicinePhiladelphia
  2. 2.Children's Hospital of PhiladelphiaUniversity of Pennsylvania School of MedicinePhiladelphia

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