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Der Einfluß von Fahrradergometerarbeit und oraler Glucose-Gabe auf die Muskel-Hexokinase-Aktivität des Menschen

The influence of bicycle ergometer work and oral glucose administration on the muscle hexokinase activity in man

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Abstract

The influence of orally administered carbohydrates and bicycle work on muscle hexokinase activity, blood glucose, and serum insulin levels were studied in 6 young men. Continuously administered glucose of a total amount of 150 g caused a significant increase in hexokinase activity within 3 hrs. Working at a load of 155 to 195 Watt led to an initial increase of hexokinase activity. At the end of the working period hexokinase activity had fallen to resting values. The possible mechanisms of action are discussed.

Zusammenfassung

An 6 jungen männlichen Probanden wurde der Einfluß von oraler Kohlenhydratgabe und Fahrradergometerarbeit auf die Muskel-Hexokinaseaktivität, den Blutglucosespiegel und die Seruminsulinkonzentration untersucht. Bei kontinuierlicher Verabreichung von insgesamt 150 g Glucose stieg die Hexokinaseaktivität innerhalb von 3 Std significant an. Unter Arbeit bei 155 bis 195 Watt stieg die Hexokinaseaktivität zunächst an und fiel mit zunehmender Erschöpfung wieder auf den Ausgangswert ab. Die möglichen Regulationsmechanismen werden diskutiert.

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Literatur

  1. Barnard, R., Peter, J.: Effect of training and exhaustion on hexokinase activity of skeletal muscle. J. appl. Physiol.27, 691 (1969)

    Google Scholar 

  2. Gerritsen, T.: On the glucokinase activity of extracts from normal and atrophic muscle. Biochim. biophys. Acta (Amst.)8, 466 (1952)

    Google Scholar 

  3. Hofer, S.: Untersuchungen über das Enzymmuster im menschlichen Muskel bei verschiedenen Formen von Myotonie. Dissertation, Med. Fak., Universität München (1969)

  4. Hoffmann, G.: Eine Modifikation der Muskelsaugbiopsienadel. Dtsch. med. Wschr.99, 1408 (1974)

    Google Scholar 

  5. Karlsson, J., Diamant, B., Saltin, B.: Muscle metabolites during submaximal and maximal exercise in man. Scand. J. clin. Lab. Invest.26, 385 (1970)

    Google Scholar 

  6. Karpatkin, S.: Soluble and particulate hexokinase of frog skeletal muscle. J. biol. Chem.242, 3525 (1967)

    Google Scholar 

  7. Karpatkin, S., Braun, J.: Solubilization and partial purification of sarcoplasmic reticulum bound hexokinase of frog skeletal muscle. Biochim. biophys. Acta (Amst.)242, 89 (1971)

    Google Scholar 

  8. Karpatkin, S., Helmreich, E., Cori, C.: The effect of anaerobiosis insulin and stimulation on hexokinase activity in frog sartorius muscle. Fed. Proc.24, 423 (1965)

    Google Scholar 

  9. Katzen, H.: The multiple forms of mammalian hexokinase and their significance to action of insulin. Advanc. Enz. Reg.5, 335 (1967)

    Google Scholar 

  10. Katzen, H., Soderman, D., Wiley, C.: Multiple forms of hexokinase. J. biol. Chem.245, 408 (1970)

    Google Scholar 

  11. Löffler, G., Weiss, L.: Radioimmunologische Bestimmung von Insulin. Mitt. Ges. klin. Chem.1, 60 (1971)

    Google Scholar 

  12. Morgan, T., Cobb, L., Short, F., Ross, R., Gunn, D.: Effects of long term exercise on human mitochondria. Advanc. exp. Med. Biol.11, 87 (1971)

    Google Scholar 

  13. Müller-Wening, D., Hoffmann, G.: Eine Biopsienadel zur Entnahme von Skelettmuskelproben. Res. exp. Med.157, 83 (1972)

    Google Scholar 

  14. Peter, J., Jeffress, R., Lamb, D.: Exercise: Effects on hexokinase activity in red and white muscle. Science160, 200 (1968)

    Google Scholar 

  15. Sharma, C., Manjeswar, R., Weinhouse, S.: Effect of diet and insulin on glucose-adenosin-triphosphate phosphotransferases of rat liver. J. biol. Chem.238, 3840 (1968)

    Google Scholar 

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Hoffmann, G., Scheder, C., Holzmüller, B. et al. Der Einfluß von Fahrradergometerarbeit und oraler Glucose-Gabe auf die Muskel-Hexokinase-Aktivität des Menschen. Europ. J. Appl. Physiol. 34, 91–96 (1975). https://doi.org/10.1007/BF00999920

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  • DOI: https://doi.org/10.1007/BF00999920

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