Abstract
Non-uniform composition in telomeric repeats at the extremities ofPlasmodium chromosomes was exploited in order to obtain data on intraclonal diversification of telomeric sequences, relevant for the study of telomere regeneration dynamics. Families of sibling telomeric clones were obtained from several chromosomal ends ofPlasmodium berghei, and analysed so as to determine the exact points from which individual clones start to diverge. As much as 90% of the telomeric tract appears to be subject to events causing abrupt changes in the sequence of telomeric repeats. The results are compatible with the hypothesis that breakpoint probability is a continuously increasing function over the entire telomeric tract.
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Dore, E., Pace, T., Picci, L. et al. Dynamics of telomere turnover inPlasmodium berghei . Mol Biol Rep 20, 27–33 (1994). https://doi.org/10.1007/BF00999852
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DOI: https://doi.org/10.1007/BF00999852