Summary
Cyclohexyalmine is considered as an indirectly acting sympathomimetic amine that can be generated by the metabolic conversion of the non-nutritive sweetener cyclamate. Sprague-Dawley rats were injected intraperitoneally with increasing doses of Cyclohexylamine. The concentration of Cyclohexylamine in the plasma was determined by means of gas-liquid-chromatography and correlated with the uptake of3H-dl-norepinephrine in the heart. Cyclohexylamine caused a dose-dependent inhibition of the uptake of3H-norephinephrine (50% inhibition by 59.0 mg/kg) and decreased the concentration of endogenous norepinephrine.
The plasma half life time of Cyclohexylamine was 75.3 min. Following a dose of 40 mg/kg, the inhibition of norepinephrine uptake lasted about 2 h. 50% inhibition was obtained at a plasma concentration of 24.8 Μg/ml of Cyclohexylamine corresponding to 2.5×10−4 M. These findings are consistent with Cyclohexylamine being an indirectly acting sympathomimetic amine which is some orders of magnitude less potent than related substances.
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Eichelbaum, M., Hengstmann, J. & Dengler, H.J. Die Wirkung von Cyclohexylamin auf die Noradrenalinaufnahme und den Noradrenalingehalt des Rattenherzens. Naunyn-Schmiedebergs Arch. Pharmak. 267, 353–363 (1970). https://doi.org/10.1007/BF00999548
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DOI: https://doi.org/10.1007/BF00999548